The tourists fell 112 runs short in an unlikely run chase under lights at Newlands as AB de Villiers' fourth ODI hundred helped South Africa level the series at 1-1.

Responding to a ground record-equalling 354 for six, even in-form Paul Collingwood's battling 86 from 82 balls could not save the day for England this time.

De Villiers' 121 dominated a home innings which included three other half-centuries at a venue where batting first is often the key to success in day-night cricket.

England are as big as 9/2 with bet365 to win the series, which heads to Port Elizabeth for game four on Sunday.