Denver quarterback Peyton Manning has broken Brett Favre's National Football League record for career touchdown passes.
A review of Sunday's action in the NFL, including a win for the St Louis Rams over defending champions Seattle Seahawks.
The Indianapolis Colts clinched a fifth straight win after easing to a 27-0 success against the Cincinnati Bengals.
The Seattle Seahawks suffered a second straight loss as the St Louis Rams clinched a shock 28-26 win at the Edward Jones Dome.
Seattle wide receiver Percy Harvin has been traded to the New York Jets in a sensational deal.
The New England Patriots needed a last-ditch blocked field goal to hang on for a tight 27-25 victory over the New York Jets.
Our betting partners Sky Bet are now offering new customers a free £20 bet when they first stake £5.
Jarryd Hayne has sensationally quit rugby league to pursue a career in American football.
Miami Dolphins have placed running back Knowshon Moreno on injured reserve with a season-ending knee injury.
Sky Bet are celebrating the return of the football season with their new loyalty scheme - the Sky Bet Club.