England will know on Friday morning whether prop Joe Marler is available for the climax to their RBS 6 Nations against Italy.
Leigh Halfpenny looks set to miss Wales' South Africa tour this summer after being ruled out "for up to four months".
England have named Manu Tuilagi on the bench for their final Six Nations match against Italy on Saturday.
Wales coach Warren Gatland has made six changes for Saturday's RBS 6 Nations finale against Scotland in Cardiff.
Ian Madigan is primed for his first RBS 6 Nations appearance of the season in Saturday's title-decider against France.
Scotland head coach Scott Johnson has made three changes to his starting XV for Saturday's Six Nations game against Wales.
France include centre Gael Fickou in one of four changes to their starting XV for Saturday's Six Nations clash with Ireland.
Sergio Parisse returns to captain Italy in their final RBS 6 Nations match against England in Rome on Saturday.
Harlequins director of rugby Conor O'Shea believes the retiring Brian O'Driscoll is "the greatest player of his generation".
Replacing Brian O'Driscoll and Gordon D'Arcy will be Joe Schmidt's toughest challenge, according to Peter Stringer.