Wales hooker Scott Baldwin will make his first RBS 6 Nations start on Saturday after edging out Richard Hibbard.
Scotland lock Grant Gilchrist's World Cup dream has been left hanging by a thread.
James Haskell has played down the importance of the choke tackle as England prepare to face Ireland.
Peter Horne replaces suspended stand-off Finn Russell for Scotland's Six Nations clash with Italy.
Team news for Friday's Aviva Premiership clash between Northampton Saints and Harlequins at Franklin's Gardens.
Wales flanker Dan Lydiate will return to Paris this week insisting he has no regrets about his flirtation with French club rugby.
England full-back Mike Brown has been ruled out of Sunday's RBS 6 Nations match against Ireland.
France coach Philippe Saint-Andre has dropped centre Mathieu Bastareaud for Saturday’s Six Nations clash with Wales.
Cardiff Blues have announced that rugby director Mark Hammett is to leave his post after just six months in charge.
Harlequins have signed Fiji back-row Natani Talei until the end of the season.