Chris Robshaw admits England's autumn outlook hinges on one final assault at Twickenham against Australia.
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Elliot Daly has been hit with a three-week ban for verbally abusing referee Ian Tempest in Wasps' defeat at Exeter.
Alex Cuthbert has no doubt that Wales are "there or thereabouts" in their continued quest to claim a major southern hemisphere scalp.
Tom Isaacs has left Gloucester to join hometown club Cardiff after just four months at Kingsholm.
David Wilson wants to make England's autumn "a lot sweeter" by beating Australia this weekend.
Wales prop Nicky Smith faces up to four months on the sidelines because of injury.
South Africa have made five changes from the 22-6 victory over Italy last weekend for their clash with Wales on Saturday.
England assistant coach Graham Rowntree says Australia captain Michael Hooper will receive "special attention" on Saturday.
Sam Burgess may make a surprise debut for Bath this Friday, just weeks after fracturing his cheekbone and eye socket.
England have named an unchanged matchday squad for Saturday's final QBE International against Australia at Twickenham.