Wales head coach Warren Gatland has warned George North that he is not guaranteed selection against England.
A further four England players have been all but ruled of the RBS 6 Nations opener against Wales.
We have a full schedule ahead of the RBS 6 Nations with results, reports and reaction to follow throughout the tournament.
Scotland boss Vern Cotter has admitted he is wary of protege Joe Schmidt catching him cold in the RBS 6 Nations.
Italy captain Sergio Parisse belives his side can beat Ireland when they meet in the 6 Nations on Saturday week.
Wales head coach Warren Gatland has warned his players not to be lured into complacency by England's injury crisis.
Sean O'Brien is set to feature in the first half of Ireland's Six Nations title defence, according to boss Joe Schmidt.
France head coach Philippe Saint-Andre believes his team's opener against Scotland will an emotional occasion.
Former England and British and Irish Lions winger Mark Cueto will bring his 14-year playing career to an end this season.
Chris Robshaw believes England cannot afford to lose their opening Six Nations game against Wales.