England v Spain - Tuesday 20:00, ITV

Gareth Southgate faces his toughest test to date as England manager when La Roja visit Wembley on Tuesday night. The Spaniards are also under new management with Julen Lopetegui having gotten off to an unbeaten start despite having some tough fixtures to navigate, winning a friendly in Belgium and picking up a point in Turin.

England have had a much more gentle schedule since they were dumped out of the Euros by Iceland and they’ve got a decent record at Wembley, losing just four times in 27 matches here since 2012. However, each of those defeats came in home friendlies against sides we have ranked higher than the Three Lions, as is the case here (we have England ranked 17th and Spain 8th in the world).

Indeed, England have lost four of their seven home friendlies against teams above them in our rankings since 2012 and given Spain’s impressive away results already under Lopetegui, they look a big price to win at 2.55. The Spaniards have conceded just twice in their last seven away matches and have won five of their eight trips to teams ranked between 11th and 40th since 2011, whilst conceding just three times.

Though some big names including Iniesta and Pique are out injured, the Spanish squad is one of great depth, with the likes of Bartra, Koke and Thiago Alcantara expected to be given starting berths and arguably benefits from being freshened up. Harry Kane has been released from international duty and unlike Spain, England don’t have an abundance in reserve as Vardy and Sturridge are both struggling for form. With that in mind, we’re backing Spain to win to nil.

Spain Win to Nil - 1pt @ 4.2