Melbourne will secure a finals berth with a victory.
It has been a vastly different story for these two teams, both entered the season with high hopes yet the Kangaroos are now a second favourite for the wooden spoon and Melbourne is on the edge of a highly anticipated return to the finals.
The Demons enter the match after a season defining 23-point victory over Port Adelaide at the MCG.
Superstar ruckman Max Gawn reminded the footy world why he is the best tap ruckman in the game in a dominant display that gave the Melbourne midfield total control of the ball.
The Kangaroos were again competitive last week against the Bombers before going down by 27 points.
While North Melbourne has played better than their season recorded of four victories suggests, they just cannot seem to win.
History though is clearly on the side of the Kangaroos for this one and as a result we expect they will be competitive and can cover the line where they are allocated a seemingly generous start of 17.5 points.
North has won their last 16 matches against Melbourne with the last Demons win in this fixture way back in Round 20 in 2006. The last time they played was Round 9 at the MCG with the Kangaroos prevailing by 14 points.
In a year that not much has gone right for the Kangaroos, the form of long haired forward Ben Brown has been a sensation.
Brown enters the round three goals off the lead in the race for the Coleman Medal and kicked a game high five goals when the sides met earlier in the season. He is in form and booted six against the Bombers last week.
The big advantage for the Kangaroos is that the game is at Blundstone Arena, a venue where they have won 10 of their past 14 matches.
While Melbourne is clearly the team to beat, the value at the line is with the Kangaroos at the plus.
Ben Brown kicked a game high five goals when these sides clashed last and should again kick the most.
NORTH MELBOURNE AT THE LINE
BEN BROWN MOST GOALS