The presumption is that defeat in Paris a fortnight ago after a home draw with Wales has cost Ireland their chance of claiming an unprecedented Six Nations title hat-trick. And that more injuries sustained against France have ended their hopes of derailing England's Grand Slam charge in Eddie Jones's first campaign on Saturday evening.
However, England have not been overly impressive in their away wins over Scotland and Italy, still turning over ball at the set-piece and breakdown like they did at the World Cup, and they lost 19-9 in Dublin last year when neutralised in the forwards and conceding plenty of penalties as well as Robbie Henshaw's try.
Get on Ireland with an eight and a half-point handicap start. The only time England have won by nine points or more in the teams' last six competitive meetings was in a Six Nations round five meeting when Wales's win at Twickenham previously meant they were on for the 2012 Grand Slam if they beat France, which they did. England only won 13-10 two years ago and Ireland won 20-16 at Twickenham in 2010.
The Ireland camp will have embraced the thought of being party-poopers in Jones's first game at Twickenham, particularly Fly-Half Johnny Sexton and understated Kiwi schemer Joe Schmidt.
Jones decided to get involved in debating Sexton's problems with concussion at a midweek press conference and his likely targeting when England have the ball. Sexton gets fired up to perform by such talk and challenges. Schmidt will have noted how England struggled in the first half in Rome a fortnight ago when Italy disrupted their forwards and targeted Fly-Half George Ford and Inside Centre Owen Farrell with some big hits. Sexton and Schmidt will have no qualms about continuing Ireland's highlighted tactics of kicking plenty of ball either. It is not as if they have been dominated by Wales and France so far and arguably, playing loose contributed to their World Cup quarter-final loss to Argentina.
Jared Payne's hamstring injury may have meant that no nonsense Henshaw has moved to Outside Centre but debutant Stuart McCloskey is built like a Lock and his game for Ulster is based on heavyweight tackles and charges with the ball in hand.
Flanker Sean O'Brien and Lock Mike McCarthy are massive outs for Ireland but they will still expect to go well at the scrum, lineout and breakdown. Ireland's scrum went well for an hour in Paris and Jack McGrath and Rory Best will relish being rejoined by fit-again stalwart Tighthead Mike Ross in the front row. And there is experienced, quality back-up on the bench in Richardt Strauss, Cian Healy and Nathan White.
Donnacha Ryan regularly switches between the backrow and second row for Munster and Ireland too. Giving Josh van der Flier his debut at Openside is less of a gamble with fellow backrowers CJ Stander and Jamie Heaslip making plenty of yards in the loose. Chris Robshaw, James Haskell and Billy Vunipola will have to spend as much time shutting them down as making their own attacking presence felt. England's set-piece is far from certain to function fluently too with Maro Itoje making his first-start at Lock. And at Scrum-Half, Ben Youngs will have his work cut out too getting away from the nagging attentions of Conor Murray.
Traditionally, England-Ireland tussles are low point-scoring affairs with low try-counts but with a fair forecast, this clash could open up, especially in the second half. England did show in Rome what they can do on the front foot and Ireland are unlikely to fold quite so readily and have X Factor on e bench in Simon Zebo. Stick to the one bet in what should be a fascinating contest.