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The Cardinals and Giants open a four-game series in San Francisco tonight, and MLB expert Mike Spector offers his insight and best play on the game.

San Francisco Giants vs. St. Louis Cardinals Prediction: Will There Be a Pitchers Duel in the Bay Area?

The St. Louis Cardinals and San Francisco Giants meet to start a four-game series in the Bay Area that could potentially be a National League playoff preview. St. Louis won four of the last six meetings between these teams last season, taking two out of three games in the home and away series.

The Cardinals’ success against the Giants was in spite of the fact that they scored more than three runs just twice in those six meetings. So is another pitcher’s duel on tap tonight? Read on for our best play in tonight’s Cardinals and Giants series opener.

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Giants vs. Cardinals Start Time and Where to Watch

  • Date: May 5, 2022
  • Game Time: 9:45 pm ET
  • Where to Watch: MLB.TV

Giants vs. Cardinals Line Movement

San Francisco Giants vs. St. Louis Cardinals Prediction

The Cardinals and Giants are each four games over .500 entering tonight’s matchup and have similarly taken advantage of weaker competition to pad their record. St. Louis and San Francisco are a combined 15-6 against teams with a losing record, but each will have to prove its mettle against bonafide division contenders.

While St. Louis will always be known as Adam Wainwright’s team as long as he dons a Cardinals uniform, Miles Mikolas (1-1, 1.52) has done an outstanding job at the top of the rotation in Jack Flaherty’s absence. Mikolas is 1-1 with a 3.31 ERA in six appearances (two starts) against the Giants but has not faced them since 2019.

Logan Webb (3-1, 3.26) is a budding star for San Francisco that still has largely gone under the radar despite going 14-4 since the start of last year. Webb does not have the best career numbers against St. Louis, going 0-1 with a 10.80 in two career starts. However, those numbers are misleading because he was rocked for eight runs (seven earned) in 2.2 innings in his first start against them in 2019. He only allowed one run on five hits in four innings when facing the Cardinals last year. Both were road starts, and we expect this to be his best outing against them in his first home start.

The Giants are getting back to full strength but are not exactly there yet. Mike Yastrzemski was activated off the COVID-19 list yesterday. Joc Pederson appeared as a pinch-hitter Tuesday as he continues to nurse a groin injury, and outfielder LaMonte Wade Jr. (knee) also rejoined the team. However, Evan Longoria (finger) and Tommy La Stella (Achilles) are still amid rehab assignments, and their absences continue to leave voids in the Giants lineup.

San Francisco is likely to be lethargic after an intense two-game series against Los Angeles, while the Cardinals’ offensive ceiling is limited with Webb toeing the rubber.

The under is 6-2 in St. Louis’ last eight road games, and we expect this game to stay under the projected total as well.

San Francisco Giants vs. St. Louis Cardinals Pick

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Article Author


Mike Spector brings unmatched knowledge and insight into the game of football, and more importantly the process of betting on NFL football. Mike is the #2 ranked expert in FantasyPros' NFL betting contest


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