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The White Sox begin a three-game home series with the Twins on Monday, and MLB expert Mike Spector weighs in with his best moneyline play for the opener.

Chicago White Sox vs Minnesota Twins Prediction: Can The White Sox Get The Win Behind Johnny Cueto?

The Chicago White Sox enter this series opener against the Minnesota Twins riding a three-game winning streak after a dominant road sweep of the Giants. Chicago has had just two winning streaks longer than three games all season, but none since May 8. 

Chicago has won its last four games against AL Central opponents, while Minnesota is 5-0 in its previous five meetings with the White Sox dating back to last year.

So which trend will win out tonight?

Read on for our prediction, best play, and odds for Monday’s series opener between the Twins and White Sox.

White Sox vs. Twins Start Time, Where to Watch, and Odds

  • Date: July 4, 2022
  • Game Time: 8:10 pm ET
  • Where to Watch: NBCSC, BSN, MLB.TV

Click Here for White Sox vs Twins Odds

White Sox vs Twins Line Movement

Chicago White Sox vs Minnesota Twins Prediction

Chicago starts this series in third place in the standings, 4.5 games back of the first-place Twins. However, oddsmakers still believe in the White Sox’s chances to win the division for the second consecutive year, as their futures odds are almost even with Minnesota’s at +145 compared to +125.

The White Sox may already be amid their midseason push to overtake the Twins, as they are 10-4 in their last 14 road games. Entering yesterday’s series finale against San Francisco, the White Sox had a collective .790 OPS in their previous 13 road games and were averaging 5.42 runs per game. Though they managed just 14 total hits in the first two wins of the San Francisco series, Chicago followed that up with 13 runs in the series finale (tied for a season-high) and five extra-base hits, though it impressively scored those 13 runs without hitting a single home run. 

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While Chicago was busy belting 17 hits yesterday, Minnesota was getting no-hit in the fifth inning by Baltimore’s Tyler Wells. Over the last 14 days, the Twins offense ranks 14th in batting average (.252) and 19th in on-base percentage (.304). We expect them to struggle again when facing Johnny Cueto (2-4, 3.33), whose .270 BABIP makes him one of two White Sox starters with a BABIP less than .313. Cueto’s 1.14 WHIP is also second among all pitchers in Chicago’s starting rotation.

Minnesota’s starting rotation is sixth-best in baseball with a 3.54 ERA, but that does not translate into success when Dylan Bundy (4-4, 4.71) pitches. The Twins are 0-5 in Bundy’s last five starts with four days of rest. He threw five scoreless innings in a start against Chicago on April 23, but the White Sox offense has been too hot lately to keep down again. The White Sox are 9-2 in their last 11 home games against Minnesota, and we expect them to take this series opener, given the Twins’ have their most vulnerable pitcher on the mound.

Chicago White Sox vs Minnesota Twins Pick

PICK: Chicago White Sox ML (-125) (Bet $125 to win $100)

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Article Author


Mike Spector brings unmatched knowledge and insight into the game of football, and more importantly the process of betting on NFL football. Mike is the #2 ranked expert in FantasyPros' NFL betting contest


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