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The Philadelphia Phillies travel to Houston on Saturday night and take on the Houston Astros. Handicapper Jason Radowitz breaks it down with his Phillies vs Astros prediction, pick, and odds.

Philadelphia Phillies vs. Houston Astros World Series Game 6 Prediction, Picks, Odds

The Houston Astros will have two chances to earn a World Series title home. They're up 3-2 against the Phillies for the World Series and will have the two remaining home games if Game 7 is even necessary.

Although the Phillies escaped Houston with a win in Game 1, Philadelphia couldn't protect home-field advantage, allowing the Astros to earn two wins on the road.

Can the Astros close out the World Series tonight, or will we have a Game 7 tomorrow night?

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Here are our picks, predictions, and odds for Saturday's game between the Philadelphia Phillies vs. Houston Astros.

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Phillies vs. Astros World Series Game 6 Start Time, Where to Watch, and Odds

  • Date: November 5, 2022
  • Game Time: 8:03 pm ET
  • Where to Watch: FOX

Phillies vs. Astros World Series Game 6 Odds

  • Run Line: Astros -1.5 (+145), Phillies +1.5 (-170)
  • Total: Over 7.5 (+100), Under 8 (-120)
  • Moneyline: Astros (-150), Phillies (+130)

Click Here for Phillies vs. Astros Game 6 Odds

Phillies vs. Astros World Series Game 6 Injury Report


No Injuries of Importance


Out: OF Michael Brantley (Shoulder), C Jason Castro (Knee)

Philadelphia Phillies vs. Houston Astros World Series Game 6 Prediction

Zack Wheeler will look to help the Phillies for a Game 7 in Houston. Wheeler is 1-2 in the postseason and isn't getting much run support. He still holds an xFIP of 2.28 with 24.3% strikeouts, and 5.2% walks over the last 30 days.

In Game 2, Wheeler threw five innings and allowed six hits, five runs, three walks, and a home run. He only struck out three and took the loss. Wheeler's in the same situation tonight, on the road, facing a great Astros offense.

Houston is hitting .183 (ISO) and a wOBA of .329 against righties over the last month. The Astros have six players hitting an above-average ISO and six hitting an above-average wOBA. Jeremy Pena, Alex Bregman, and Kyle Tucker have easily been the best hitters against righties in the last month for the Astros. Still, they're getting solid production from everyone not named Jose Altuve and Martin Maldonado. Those two have been very inconsistent offensively.

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However, Altuve hit a triple against Noah Syndergaard in Game 5 to set the tone and help the Astros score first.

The Astros have also struck out under 22% of the time against righties and have walked nearly 8% of the time against righties.

On the other hand, Framber Valdez will get the start for the Astros. He also matched up against Wheeler in Game 2 and outpitched him.

Valdez went 6.1 innings and allowed four hits and one run while accumulating nine strikeouts. Valdez also walked three batters in that game but was able to tip-toe around trouble with a high ground ball and strikeout rate.

He has an xFIP of 1.77 over the last 30 days and has struck out 32.4% of batters in the previous 30 days. Now he'll take on a Phillies lineup with a .127 ISO and wOBA of .320. The Phillies have struck out against lefties 26.2% of the time and have walked under 6%.

But what's more alarming is that the Phillies have hit 62.5% of grounders over the last 30 days against lefties. That will continue against Valdez, one of MLB's best ground ball pitchers.

I like Wheeler to step up and believe Valdez should get by without allowing much damage. Therefore, I'll rock with the Under 7 in tonight's game.

If you're looking to bet on a side, I'd go with the Astros. I'll play it safer and cheer on a pitcher's duel.

Philadelphia Phillies vs. Houston Astros Pick

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Article Author


Jason grew up an avid sports fan. His passion for sports writing grew in high school and he developed a blog that was strictly for New York Sports. From his work, you will quickly realize that he loves looking at games from an analytical and numbers perspective and hopes to provide you with that same perspective in his articles.


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