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Oklahoma State vs. Kansas prediction and pick. Oklahoma State Cowboys travel to play the Kansas Jayhawks during a noon ET kickoff at the David Booth Kansas Memorial Stadium in Lawrence, Kansas on Saturday. NCAAF handicapper Matt MacKay is here with his predictions.

Oklahoma State vs. Kansas Pick, Prediction, Pick, and Odds: Will Spencer Sanders, Cowboys Bounce Back?

There is no sugar-coating recent performances for either of these Big 12 teams ahead of a Week 10 matchup in Lawrence, Kansas. Oklahoma State was outmatched from start to finish in a 48-0 shutout loss to Kansas State in Week 9, while Kansas' last game resulted in a 35-23 road loss to Baylor in Week 8. Both teams are still in the mix for a Big 12 Championship appearance but they will need to improve quickly to go on a winning streak down the stretch.

Kansas lost star quarterback Jalon Daniels to a shoulder injury against TCU a couple of weeks ago, which forced back-up Jason Bean under center. Bean played well against the undefeated Horned Frogs but he has failed to deliver a win against Oklahoma and Baylor. Will the Jayhawks bounce back after their Bye Week? Or will the Cowboys put last week's dismal performance behind them and get back in the win column? Here are our picks, predictions, and odds for Saturday's Big 12 matchup between the Oklahoma State Cowboys vs. Kansas Jayhawks.

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Oklahoma State vs. Kansas Start Time and Where to Watch

  • Date: Saturday, November 5
  • Game time: 3:30 p.m. ET
  • Where to Watch: FS1

Oklahoma State vs. Kansas Odds

  • Spread: Oklahoma State -3.5 (-105), Kansas +3.5 (-115)
  • Total: Under 69 (-110), Over 69 (-110)
  • Moneyline: Oklahoma State (-165), Kansas (+140)

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Oklahoma State vs. Kansas Injury Report

Oklahoma State

RB Dominic Richardson (DTD - Undisclosed), WR Braydon Johnson (DTD - Undisclosed), WR Jaden Bray (DTD - Undisclosed), WR Blaine Green (Out - Wrist)


TE Will Huggins (Questionable - Undisclosed), S Jayson Gilliom (Questionable - Undisclosed), OL James Livingston (Questionable - Foot), WR Trevor Wilson (Suspension), QB Jalon Daniels (Questionable - Shoulder)

Oklahoma State vs. Kansas Prediction

This game has one of the highest point total lines across the Week 10 slate. That's because neither defense ranks inside of the top 100 units out of 131 Division I FBS programs. Oklahoma State has had to rely on junior quarterback Spencer Sanders to get it done through the air and on the ground, but it became too big of a burden to carry against Kansas State's defense in Week 9. Across his last four games, Sanders has three finishes with under a 50 percent completion rate. This is a red flag and concerning ahead of another road contest in Kansas.

The Jayhawks have been reeling ever since the loss of Daniels against TCU. Jason Bean exceeded expectations and nearly won the game against TCU, but his last two outings against Oklahoma and Baylor have been pedestrian at best. Bean is capable of generating production as a passer, but he has thrown three touchdowns across the last two games while committing three interceptions.

Kansas has a volatile rushing attack led by Devin Neal and Daniel Hishaw Jr., but the absence of Daniels has made it a lot more difficult to establish the run at the line of scrimmage. For all of Oklahoma State's flaws on defense, they can lock down coverage in the secondary from time to time. The Cowboys have held opposing passers under a 60 percent completion rate in three consecutive games, but they couldn't force a turnover against Kansas State last weekend. It was an anomaly, as Oklahoma State tends to rack up one to two turnovers per game on defense.

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Kansas has been no match for Oklahoma State in this head-to-head series recently, winning five straight dating back to 2017. The arrival of Daniels in Lawrence led to an early break-out campaign and he is tagged as questionable with his shoulder injury coming off of the Bye Week. It's a critical piece to solving the lines in this Big 12 showdown.

Since losing to TCU, the Jayhawks have dropped two more games, but both were on the road. Granted, Tennessee Tech, Duke, and Iowa State are not high-caliber opponents, but Kansas' only home loss of the season came at the hands of the undefeated TCU Horned Frogs. It was also the game where Daniels went down, forcing Bean into the starting role. Conversely, both of Oklahoma State's losses have been on the road in three weeks. The defense is allowing at least two passing touchdowns per game lately while surrendering over 5.0 YPC and two touchdowns on the ground.

The point total line at 69 is enticing, but it does present risk with the chance for a push. Plus, which defense will we get from these teams? The good or the bad? Kansas' run defense is dreadful, allowing nine rushing touchdowns during the last two weeks. However, its pass defense has only looked bad against West Virginia and TCU. This could be a game where Sanders goes ballistic as a ball carrier, but if he cannot get going through the air, it could lead to another long day for the Cowboys' offense.

I'm most comfortable rolling with Kansas to cover the spread as 3.5-point underdogs at home. -115 is still a good value for the Jayhawks to lose by three or fewer, and much safer than betting on them to win outright at +140 on the moneyline. I expect Oklahoma State to regroup and engage in a back-and-forth offensive battle in Lawrence, with the Jayhawks losing another close one at home.

Oklahoma State vs. Kansas Pick

Article Author


Matt is an avid writer, editor, and researcher. He enjoys analyzing the game within the game which is fantasy sports and sports betting. Music is another constant in his daily life. Matt loves spending time with his wife and three pets. He likes to read, listen to podcasts, and is constantly motivated to create the most accurate and engaging content in the sports betting industry.


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