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Louisville and Ole Mis both kick off their season on Monday in the Chick-fil-A Bowl. Check handicapper Brian Good's Louisville vs. Ole Miss prediction and pick.

Louisville vs. Ole Miss Prediction: Can Louisville Hang With Ole Miss Offense?

Lane Kiffin has had a lot of jobs over the past decade. Some have seemed to fit him pretty well, like offensive coordinator at Alabama and head coach at FAU, and some have fit him poorly, like his stops in Tennessee and Oakland. But, it does seem like the fit between Kiffin and Ole Miss is a match made in heaven.

Last season, if his first year at Oxford, the team had varying amounts of success from week to week, but one thing they did every time out was score points.

Lane Kiffin turned the Ole Miss offense into a well-oiled machine, and I expect that to continue this year. Not only do the Rebels have their head coach of the future, but they also have one of the most explosive quarterbacks in the country in Matt Corral.

Ole Miss opens the season up against Louisville on a rare Monday night kick-off in the week we have before the start of the NFL season. What can we expect from Louisville and Ole Miss

My Lousiville vs. Ole Miss predictions start with points.

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Louisville vs. Ole Miss Prediction

We are expecting a ton of points in this one. Ole Miss' offense was flat-out unstoppable last season. They were the third in the nation with 556 yards per game and put up 39 points per contest. They did that while playing in the SEC. So, any Louisville vs. Ole Miss prediction is going to be calling for points. But remember, the 75.5 tota is the biggest number on the board across college football Week 1.

Granted, SEC defenses last season were not what they have been in the past, but it's still an insanely impressive year for the Rebels in their first year under Lane Kiffin.

Ole Miss lost a few of its weapons on the offensive side of the ball, but they returned their quarterback, Matt Corral. That's something teams like Alabama, Georgia and Florida can't say.

On the other hand, it's important to point out just how much talent Louisville has lost on defense, especially in their secondary and linebacking corp.

LBs Rodjay Burns and Dorian Etheridge are gone and will leave massive holes. CJ Avery is back but he will be the only one returning, which is not just going to hurt their ability to stop the run but also play in space against this fast Ole Miss offense.

CB Kei'Trei Clark is back and will no doubt be a difference maker on Monday, and throughout a long ACC schedule, but I'm not sure about the depth of this Cardinals secondary.

I'm staring this 75.5-point total in the face and I'm still not scared of taking the over. I bet one Ole Miss under last season and I think it went over in the first half. Lane Kiffin loves to score points and has admitted he checks out the lines and totals before the game.

Kiffin knows people are expecting fireworks and he is going to put on a show come Monday night.

Matt Corral was part of a QB-by-committee situation last year but it's his show in 2021. I love that he completed a high percentage of his passes last year and put up points. We need to see how he does without receiver Elijah Moore, who is now a New York Jet, but I think he will pick up where he left off.

We know the Louisville offense can also put up points. Last year, the Cardinals didn't know what they had in QB Malik Cunningham. Now they know he can play and the job is all his, despite Luke McCaffrey being there for all of like 10 days before leaving.

Like Ole Miss, the Cardinals will need to replace missing production at receiver, but I think we get a serious shootout. 56-42 isn't too far out of the realm of possibilities.

So, not only am I taking over the 75.5 total, but I'm also backing Kiffin and the Rebels to cover as I think the Louisville offense is good and can hang with Corral and Ole Miss for a bit, but eventually, they pull away.

Click here for complete Louisville vs. Ole Miss odds

Louisville vs. Ole Miss Pick

Over 75.5 points @ -110

Ole Miss -10 @ -115

Louisville vs. Ole Miss Odds & Information

Date: Monday, September 6

Time: 8:00 PM ET

Location: Mercedes-Benz Stadium (Atlanta, GA)

Ole Miss Record: 0-0 (0-0 SEC)

Louisville Record: 0-0 (0-0 ACC)

TeamPoint SpreadMoneyline OddsTotal
Ole Miss-10.5-370Over 75.5 (-110)
Louisville+10.5+320Under 75.5 (-105)

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Article Author


Brian is a sports journalist with close to ten years of experience in the business. A lifelong Philadelphia sports fan with a passion for all things sports gambling.


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