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Week 10 college football predictions for Saturday's action and one pick from Friday night. College football expert Brett Ciancia is back, giving us his top betting picks for the weekend.

Week 10 College Football Predictions: Saturday's Best Bets From Across The Country

College football expert and analyst Brett Ciancia is back, giving us his best bets for Saturday's Week 10 games. Brett breaks down all four of his picks, most of which come to us from marquee games like Ole Miss vs. Liberty and Oklahoma State vs. West Virginia. He also has a pick for Friday night's maychup between Stanford and Utah you don't want to miss!

Make sure you check back each week to see Brett's Saturday college football picks and best bets throughout the entire season.

College football odds for every single game on Saturday

Baylor vs. TCU Prediction

At the start of November, Baylor finds themselves in a 3-team Big 12 race, and in the Top 15 of the initial Playoff rankings.  Head coach Dave Aranda deserves a ton of credit for installing his complex defense and seeing the strong results already in year two.

Even better, Baylor checks in at #5 in Pick Six Previews’ Game Grader formula, which is essentially power ratings that measure statistical dominance and adjust for opponent strength.  Abram Smith has surprised at running back after transitioning from linebacker.  The offense leads the Big 12 in yards/play, while the defense is among the Top 3 in most statistical categories.  They also limited former Heisman candidate Bijan Robinson to just 41 rushing yards in their win over Texas last week.

Meanwhile, TCU is coming off of a shocking midseason firing of long-time head coach Gary Patterson.  He led TCU to two decades of success, undefeated seasons, BCS, and Rose Bowl appearances, and improved the program so much that they moved up from the Mountain West to the Big 12.  Distractions must be running wild.  It doesn’t help that their defense is statistically one of the nation’s worst.

Baylor is 5-0 ATS at home, but even on the road they are still undervalued.

Prediction: Baylor 31, TCU 20

Pick:  Baylor -7  (-110)

Utah vs. Stanford Prediction

Utah’s offense has led the conference since their quarterback switch from Charlie Brewer to Cam Rising.  The rushing attack is consistently ripping off chunk plays, which opens up play-action passes.  Coordinator Andy Ludwig is back to getting his tight ends involved in numerous ways.

Utah has now swept the Pac-12 South contenders – Arizona State, USC, UCLA – and all by double-digits.

Stanford had a hot streak for a few weeks, but have fallen off, especially on offense.  They failed to score a touchdown for the majority of the Washington game last Saturday night.  There is also a possibility that starting quarterback Tanner McKee is out Friday night, meaning the weak offense from the opening game could return against a very strong Utah defense.

Prediction: Utah 26,  Stanford 13

Pick: Utah -9  (-110)

Oklahoma State vs. West Virginia Prediction

Oklahoma State is another team that is rated far higher in Pick Six Previews’ Game Grader formula, relative to their new Playoff ranking.  Oklahoma State is #4 nationally in Game Grader, and has had a strong season behind a powerful run game and stout defense.  Jaylen Warren is the best back you haven’t heard of yet.

But it’s the defense that has led the charge.  Oklahoma State leads the entire Big 12 in scoring defense (18.0 points/game), and in yards/play (4.6).  This is a clear advantage against a West Virginia offense that has struggled at times, and called into question whether they should move on at quarterback.

Prediction: Oklahoma State 27, West Virginia 17

Pick:  Oklahoma State -3  (-110)

Ole Miss vs. Liberty Prediction

Hugh Freeze gets a shot at his former program, in an intriguing early November non-conference game.  Liberty held their own against Power 5 competition back in 2020, however they lost to Syracuse this year in their only P5 test.

Ole Miss is led by a Heisman contender quarterback Matt Corral.  His stats are certainly Heisman caliber – efficient passing, touchdowns, and also a ton of production in the rushing game.  If Liberty struggled and lost to Syracuse, Ole Miss will overpower them.

Prediction: Ole Miss 41, Liberty 24

Pick: Ole Miss -9  (-110)


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