Odds format
United States
Share to Facebook
Share to Twitter
Copy Link
The Syracuse Orange will look to continue their improbable season with a road matchup against the Clemson Tigers. Both teams are undefeated so which will break that streak? Jason Radowitz answers.

Clemson vs. Syracuse Prediction, Pick, Odds: Can DJ Uiagalelei, Clemson Stay Undefeated Against Syracuse?

The Syracuse Orange will look to continue their improbable season with a road matchup against the Clemson Tigers. Syracuse has started the season 6-0 after a significant home win against North Carolina State. However, the Orange took on NC State's backup quarterback and have played mostly home games this season. Now they'll head over to Clemson to take on a Tigers team that is currently 7-0. The Tigers have also been tested by North Carolina State and defeated them. Meanwhile, Clemson also escaped Wake Forest and Florida State this season. A win against Clemson would put Syracuse in the Top 10. Will it happen?

Here are our picks, predictions, and odds for Saturday's game between the Syracuse Orange vs. Clemson Tigers.

Clemson Tigers vs. Syracuse Orange Start Time, Where to Watch, and Odds

  • Date: October 17, 2022
  • Game Time: 12:00 pm ET
  • Where to Watch: ABC

Clemson vs. Syracuse Odds

  • Spread: Clemson -13.5 (-110), Syracuse +13.5 (-110)
  • Total Odds: O/U 51 (-110)
  • Moneyline Odds: Clemson (-560), Syracuse (+430)

Click Here for Clemson vs. Syracuse Odds

Error fetching data.

Clemson vs. Syracuse Injury Report


Out: DB Dom Foster (Suspension)


Out: DE Justin Foster (Undisclosed), RB Kobe Pace (Ankle)

Bet $5, Win $200 Extra on your favorite CFB Moneyline now, with this HUGE DraftKings promo code!

Clemson Tigers vs. Syracuse Orange Prediction

Although Syracuse has been tested, most games have come at home. Syracuse will go through a gauntlet in the ACC, with many road games that will try them. First up is Clemson. The Orange have scored 36 points per game while allowing just 13.2 points. The offense averages 432.8 yards per game behind an excellent offensive line. Garrett Shrader has thrown 12 touchdowns and 1434 yards at quarterback this season. He's also tossed three interceptions. But overall, he's a bruising quarterback who isn't afraid to run for the first down and take a hit. Meanwhile, the Orange are getting great production out of Sean Tucker, who has six touchdowns on 124 carries. Tucker has rushed for 644 yards this season and continues to impress with his speed and quickness. On defense, the secondary has been the most exciting portion of the defense. Syracuse has held teams to under 175 passing yards per game. The pass rush isn't all that effective, but with the secondary playing so well, the entire defense has been able to feed off that production. The Orange are also excellent against the run, holding teams to 95 yards per game.

On the other hand, Clemson's finally getting solid quarterback play out of D.J. Uiagalelei. He's thrown for 1665 yards with 17 touchdowns and just two interceptions. Will Shipley has also produced at running back with 567 yards and eight touchdowns on 96 carries. The run block hasn't been great for Shipley, but he's a playmaker. He can find holes and create offense with his feet, regardless. Defensively, Clemson's pass rush is electric. The run defense is crazy good, and the secondary has played very well. This will be Syracuse's biggest challenge yet offensively.

The Tigers have allowed 82.7 yards per game on the ground this season. If Syracuse wants to succeed, they'll need a solid plan to pass the football. With how well Clemson's pass rush has been, Shrader will likely make some mistakes throwing the football, leading to a Clemson victory by more than 13.5 points. The Syracuse dream won't be alive after a loss to Syracuse.

Clemson Tigers vs. Syracuse Orange Pick

Looking for the best sportsbook offers? Check out the free bets page

Error fetching data.

Article Author


Jason grew up an avid sports fan. His passion for sports writing grew in high school and he developed a blog that was strictly for New York Sports. From his work, you will quickly realize that he loves looking at games from an analytical and numbers perspective and hopes to provide you with that same perspective in his articles.


Almost there!

We are loading your bets, and they will be here in a second.