NFL Picks Against The Spread: Buffalo Bills vs. San Francisco 49ers Predictions

Game No. 2 tonight between the Bills and 49ers is sure to be a battle, but who should you be backing? Davis Mattek has the answer
Davis Mattek
Mon, December 7, 11:25 AM EST

Buffalo Bills vs. San Francisco 49ers Predictions

In our nightcap, Davis Mattek breaks down three picks for MNF between the Bills and 49ers. The spread, which has been moving all day, looks a little off, which is something we'll look to take advantage of in order to get some value on that and the moneyline.

Watch the full video here:

 

Buffalo Bills vs. San Francisco 49ers Picks:

Bills +1 @ -105

Bills ML @ +100

Under 48 @ -102

Our team of NFL handicappers, featuring Davis Mattek, Ben Gretch, Ben Rolfe, Richard Johnson and Alex Kirshner, bring us their picks every week, providing the best NFL betting analysis you can find anywhere on the internet.

Monday Night Football: Buffalo Bills vs. San Francisco 49ers Latest Odds

Click odds to place bet

Moneyline

Buffalo Bills @ +100

San Francisco 49ers @ -120

Spread 

Buffalo +1.5 @ -110

San Francisco -1.5 @ -110

Total Points 

Over 48 @ -105

Under 48 @ -106

Monday Night Football: Buffalo Bills vs. San Francisco 49ers Information 

The Niners are injured and 5-6 on the season, but they still come in as the favorite over a 7-3 Buffalo team that leads the AFC East. Usually, that means the oddsmakers know something the betting public doesn't, but I guess we'll find out. Nick Mullens is starting at QB for San Francisco, and while he's had some success, the Buffalo secondary is very good an could give him issues.

Bills +1 @ -105

Davis Mattek
@davismattek
You'll know him from Twitter. Davis lives best ball, dynasty and all things fantasy!
Jan 2021
Record
Wins
12
Losses
9
Push
0
ROI
-1.43%
0Betslip

Almost there!

We are loading your bets, and they will be here in a second.

Bonus Bets$300 Preakness BonusPreakness Stakes: Get A $300 Risk Free BetCLAIM OFFER