NFL Picks Against The Spread: Buffalo Bills vs. San Francisco 49ers Predictions
In our nightcap, Davis Mattek breaks down three picks for MNF between the Bills and 49ers. The spread, which has been moving all day, looks a little off, which is something we'll look to take advantage of in order to get some value on that and the moneyline.
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Buffalo Bills vs. San Francisco 49ers Picks:
Bills +1 @ -105
Bills ML @ +100
Under 48 @ -102
Our team of NFL handicappers, featuring Davis Mattek, Ben Gretch, Ben Rolfe, Richard Johnson and Alex Kirshner, bring us their picks every week, providing the best NFL betting analysis you can find anywhere on the internet.
Monday Night Football: Buffalo Bills vs. San Francisco 49ers Latest Odds
Click odds to place bet
Buffalo Bills @ +100
San Francisco 49ers @ -120
Buffalo +1.5 @ -110
San Francisco -1.5 @ -110
Over 48 @ -105
Under 48 @ -106
Monday Night Football: Buffalo Bills vs. San Francisco 49ers Information
The Niners are injured and 5-6 on the season, but they still come in as the favorite over a 7-3 Buffalo team that leads the AFC East. Usually, that means the oddsmakers know something the betting public doesn't, but I guess we'll find out. Nick Mullens is starting at QB for San Francisco, and while he's had some success, the Buffalo secondary is very good an could give him issues.