NFL Picks Against The Spread: Buffalo Bills vs. New England Patriots Predictions

Buffalo Bills vs. New England Patriots Predictions

Week 16's Monday Night Football matchup between the AFC East Champion Bills and Patriots is the final MNF game of the season. The Bills come in as massive favorites over the Pats, who will miss the playoffs for the first time since 2008. Davis Mattek doesn't love the total and there isn't a lot of value on the moneyline, but he does have a play for the point spread.

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Davis' Buffalo Bills vs. New England Patriots Picks:

Bills -6.5 @ +110

Our team of NFL handicappers, featuring Davis Mattek, Ben Gretch, Ben Rolfe, Richard Johnson and Alex Kirshner, bring us their picks every week, providing the best NFL betting analysis you can find anywhere on the internet.

Monday Night Football: Buffalo Bills vs. New England Patriots latest odds

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Moneyline

Buffalo Bills @ -334

New England Patriots @ +305

Spread 

Bills -6.5 @ -110

Patriots +6.5 @ -110

Total Points 

Over 46.5 @ -110

Under 46.5 @ +100

Monday Night Football: Buffalo Bills vs. New England Patriots Information 

Usually, when the Bills and Patriots play late in the season and one team has already clinched the division and the other has nothing to play for, tonight's roles are reversed. But 2020 is the year of surprises and the Patriots have already been knocked out of the playoff race. Will the Patriots come to play with nothing on the line?