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In what should be one of the best matchups of the week, Matt O'Leary makes his pick for the Cleveland Browns vs Arizona Cardinals in Week 6.

NFL Week 5 Picks: Cleveland Browns vs Arizona Cardinals Predictions, Picks & Odds

Week 5 saw a devastating loss for the Cleveland Browns. After going up 27-13 in the third quarter, they fell apart and the fourth quarter saw Justin Herbert lead his team to a 47-42 victory over the Browns. That’s twice now that they blew late leads on the road.

Now, they head home to host the unbeaten Arizona Cardinals. Arizona sits at 5-0 and after a down week offensively, they sit at fourth in points for and sixth in yards. Do they get back in gear and continue their winning ways on the road or is this their first loss of the season?

Cleveland Browns vs Arizona Cardinals Betting Odds

Cleveland Browns vs Arizona Cardinals Predictions

The Browns have been weird so far this year. They’ve had some dominant defensive performances, like allowing just 13 points to the Bears and Vikings over a two-week period and then just a complete second-half meltdown like what we saw last week and against Kansas City.

While Baker Mayfield has been off to a slow start, the run game has been unbelievable. Nick Chubb and Kareem Hunt have the league’s best statistics as they already have 12 rushing touchdowns and 938 yards between the two of them.

For Arizona, sure the offense has been great, and overall they have their defense has been good allowing the sixth-fewest points but this week there’s a chance they struggle. They’ve allowed the fourth-most rushing yards in the league so far this season.

Opponents are averaging 5.39 yards per carry against this defense and just last week, they let up 5.43 yards per attempt on the ground to San Francisco. Asking them to contain Chubb and Hunt seems like an impossible task. Granted, offensively they’ve been really good so perhaps that mitigates some of their issues in the run game but if you’re looking for an advantage that’s one that jumps out.

Cleveland holds a 3-2 record against the spread this year while Arizona sits at 4-1 in 2021. At home, they’re just 1-1 but in non-conference games since 2020 they hold a 6-0 record. The Cards are 3-3 in non-conference games but as a road dog are 4-2 with a +12.4 ATS +/-.

Honestly, on paper, the Browns here have the better roster they’ve just had a couple of tough breaks against two of the best quarterbacks in the entire league. The Cardinals might’ve shown last week that they’re a little more beatable than we thought.

This is one of the more difficult games that I had to pick this year, but I think I’m going with the home favorite. They really can’t afford to lose two in a row especially with the Bengals taking on the Lions and the Steelers taking on the Seahawks without Russell Wilson. They’re the more desperate team and Arizona has some breathing room.

Cleveland Browns vs Arizona Cardinals Pick

Browns -2.5

NFL Free Picks: Week 6 is here after a wild Week 5. Week 5 saw Cordaralle Patterson and Kyle Pitts dominate the world stage in London. The Packers and Bengals back and forth overtime game with tons of botched field goals. Tom Brady and company continue to dominate. The Bills rolled over the Chiefs and are now AFC title favorites. The Patriots, Eagles, and Chargers all come out on top with 4th quarter comebacks. Kyler Murray and the Cardinals remain the lone unbeaten team and much, much more. This week, we'll see an NFC clash between the Buccaneers and Eagles on Thursday Night Football -- that one should be a ton of fun. A rivalry as old as time as the Green Bay Packers and Chicago Bears square off. The Arizona Cardinals put their undefeated record on the line against the Cleveland Browns and on Monday Night Football the Buffalo Bills will look to stay red hot facing the Tennessee Titans. Hang with OddsChecker and you'll get free picks for every NFL game this week from Ben Gretch, Derrik Klassen, Justis Mosqueda, Nate Tice, Katelyn Heffler, Geoff Fienberg, Jason Radowitz, Matt O'Leary, Mike Spector and more. Plus you'll be able to compare the best odds from legal sportsbooks, too.

Article Author


OddsChecker sports writer Matt O'Leary brings experience sports betting advice to the OC staff. You may recognize Matt from his popular New York Jets youtube channel, but his vast knowledge of sports and betting goes well past the boundaries of New York.


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