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WHo do our contributors and staff writers think are the biggest lock of the weekend this week in the NFL? Find out here with our staff picks

NFL Betting Picks Week 6: Our Staff's Locks of the Week

If you're anything like me, you've walked into Target too many times to count and your head starts spinning because you can't figure out what unnecessary item to purchase first.

Sports betting is essentially the same.

These days, there are thousands of bets you can place each week of the NFL season, and narrowing it down can be a daunting task. The friendly staff at OddsChecker is here to help!

Every week, in addition to an ever-growing abundance of top-notch content, our staff will be providing us with their favorite overall plays each week of the season. Now, unlike shopping at Target, where you don't leave until you've purchased the entire store, our staff can only pick one bet.

For this piece, our staff will be covering whatever Week 5 bets they feel strongest about -- no limitations. Let’s get to it!

Top Week 6 NFL Bets and Predictions

Cleveland Browns -3.5 (+100)

It appears extensive COVID-19 protocols are about to hit the Cardinals -- Chandler Jones appears certain to be out of this contest. The Browns are getting healthier and will bounce back in a big way after a tough loss to the Chargers.

-- Geoff Fienberg (@gfienberg17)

Seattle Seahawks +5.0 (-105)

The Steelers are close to a touchdown favorite against the Seahawks and it just doesn't make sense. At the end of the day, losing Russell Wilson for a month will hurt but Smith is capable of producing with an offense that has so many weapons. The Steelers defense has not been great in the secondary and that should allow Smith to get in a groove. And while the Seahawks have been awful defensively, who trusts the Steelers' offense right now? Not me.

-- Jason Radowitz (@Jason_Radowitz)

Chargers +3 (-120)

I already went over this is my game preview for this one. But, these two teams are pretty evenly matched. The Chargers can air it out on anyone and the Ravens have proven they can do the same. The difference here comes on the defensive end. LA gives up just 214 yards per game through the air. Meanwhile, Baltimore is giving up 296.4 pass yards to opponents per game. We just saw Carson Wentz tear this Baltimore defense up. Justin Herbert is a much better quarterback than he is and should have a field day. Both these teams are good, give me the points with two strong AFC squads going head to head.

-- Brian Good (@BeGood1219)

Houston Texans +10 (-105)

The Indianapolis Colts just allowed the Ravens to complete their third-biggest comeback in franchise history, after blowing a 16-point fourth-quarter lead and losing in overtime. The Colts' defense had absolutely no answers for Lamar Jackson in the second half, and their mounting injuries are a cause for concern going forward. I am not sure Indianapolis should be favored by double digits over anyone in the league, let alone a Texans team that finally showed some life under Davis Mills last week. Mills became the first rookie quarterback since 2012 to throw for 300+ yards against a Bill Belichick-coached team and will use that momentum to pick apart a ravaged Colts secondary this week.

-- Mike Spector (@MikeSpector01)

Cleveland Browns vs. Arizona Cardinals Over 52.5 Total (+140)

Both these teams score, and score a lot. Arizona ranks fourth in the NFL in scoring while the Browns are sixth. On average, the Cardinals are sitting at 31.4 points per game (even after their down week against San Francisco) and Cleveland is at 28.4. Expect this one to be a shootout as both teams play a fast-paced with the total going comfortably into the 50's.

-- Matt O’Leary (@MattOLearyNY)

Austin Ekeler Over 36.5 Receiving Yards (-115)

Austin Ekeler is a vital weapon for the Los Angeles Chargers offense. He has 5 or more targets in each of his last 4 games. He's had over 50 receiving yards in 3 of the last 4 games. The Baltimore Ravens have struggled against running backs this season. They've allowed a running back 50+ receiving yards in 3 of 5 games this year, including 116 receiving yards to Jonathan Taylor last week. Ekeler can easily hit the over on 36.5 receiving yards on 1 or 2 receptions. Given his involvement as a pass-catcher, this receiving number seems pretty low.

-- Nate Hamilton (@DomiNateFF)

James Robinson to Score Anytime (+125)

Robinson has scored a touchdown in three straight weeks! He's going to make it five in a row when the Jaguars play the Dolphins in London. Miami has been AW-FUL defending the run so far in 2021. Robinson has at least three carries inside the red zone the last three weeks. He is out-snapping all other Jaguars running backs, like he should be, at an alarming rate! He has averaged 4.21 YAC per attempt which is best in the NFL and is averaging the second-most yards per attempt at 5.8 yards. Miami has allowed the second-most touchdowns to running backs so far and the fourth-most rushing yards. I expect Robinson to take full advantage of his opportunities! London calling! Best of luck if you tail!

-- Tom Viera (@Tom_Viera)

Darrell Henderson 70+ Rushing Yards and 10+ Receiving Yards (+160) - DraftKings

I've already had success with one Darrell Henderson parlay this year, so I'm going to go back to that well once again for Week 6. So far this season, the Giants have allowed four different running backs to record at least 75 rush yards against them, and they allowed 69 to a fifth back. New York has also surrendered at least 17 receiving yards to five different runners this season. Meanwhile, Henderson has had 70 or more rush yards in each of his three fully healthy games, and he's had 17 or more receiving yards in every game this season.

-- Elisha Twerski (@ElishaTwerski)

Article Author


The Senior Editor at OddsChecker, Elisha is an experienced fantasy and betting analyst. According to BettingPros, he was was one of the most accurate betting experts in 2019, ranking second in moneyline picks and 13th against the spread. Originally from Milwaukee, Wisconsin, his best skill is his ability to spell "Antetokounmpo" without looking. You can follow Elisha on Twitter at @ElishaTwerski.


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