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NFL betting expert Derrik Klassen shares his three favorite same-game parlays from Week 16 of the 2021 NFL season.

NFL Week 16 Picks: 3 Best Same-Game Parlays

Los Angeles Rams at Minnesota Vikings Two-Leg Parlay (+310)

Leg 1: Los Angeles Rams -3.5 Things have only continued to get worse for an already-cursed Vikings team this season. After months of weird losses despite overall team efficiency, the Vikings suffered their most embarrassing loss of all by falling to the Lions in the first week of December. Since then, the Vikings eked out wins over the Steelers and Bears, but they remain a team that is not to be trusted week-to-week. This week, in particular, the Vikings will be without starting running back Dalvin Cook due to him being placed on the COVID IR list. While backup Alexander Mattison is fine, he does not provide nearly as much of the explosive potential as Cook does. Put that up against a Rams offense that is finding their rhythm again and it's not hard to see how the Rams outscore the Vikings somewhat handily in this one.

Leg 2: Rams WR Odell Beckham Jr., Anytime TD Scorer Minnesota does not have any single cornerback who can go 1-on-1 with Odell Beckham Jr. Between the 20s, Mike Zimmer will surely find ways to bracket Beckham Jr. or provide extra help to his side on occasion, but when the defense gets stuck in the red zone and OBJ gets to make use of his elite explosiveness and agility in the condensed field, that is an advantage for the Rams. Passing touchdowns are generally easier to come by against the Vikings, too. The Vikings have allowed 1.8 passing touchdowns per game this season, which ties for the fifth-worst rate in the league. Conversely, they have allowed just 0.9 rushing touchdowns per game, tying them for 13th in the league. Beckham Jr. continues to grow more and more comfortable in the Rams offense with each week and this is the perfect matchup for him to find the end zone.

Buffalo Bills at New England Patriots Two-Leg Parlay (+300)

Leg 1: Bills QB Josh Allen, Over 34.5 Rushing Yards

Leg 2: Bills QB Josh Allen, Anytime TD Scorer In general, the Bills have relied on Josh Allen less as a runner with each passing season. They want him to be more a focal point of the passing game and not have to use his body as a runner as much. However, offensive coordinator Brian Daboll has generally been more willing to turn back to Allen as a runner in high leverage games and situations. No game is more high leverage than a late-season game in Foxborough with the division potentially on the line. That alone should lend to the Bills leaning more on Allen as a runner, particularly once they get to the red zone and need to use the numbers advantage created by having the quarterback involved in the run game. The Bills will also be without some of their receivers in this game. Wide receiver Cole Beasley was the first to be added to the COVID IR list earlier this week. Near the end of the week, fellow wide receiver Gabriel Davis was also put onto the COVID IR list. Additionally, though not on the COVID list, wide receiver Emmanuel Sanders is working back from a knee injury that knocked him out of the Week 14 game and may not be 100% for this matchup. With so many of Buffalo's receiving options either out or limited, it's not hard to imagine Allen having to scramble for his life on a few occasions and working towards that 34.5 rushing yards mark.

Want to build your own parlay? Check out OddsChecker's parlay calculator to see what kind of odds your parlay will net!

Baltimore Ravens at Cincinnati Bengals Two-Leg Parlay (+425)

Leg 1: Bengals QB Joe Burrow, Over 279.5 Passing Yards

Leg 2: Bengals QB Joe Burrow, 3+ Passing Touchdowns Joe Burrow had arguably his best game of the season the last time he faced Baltimore. At the time, the Ravens secondary was healthier and their offense was theoretically better equipped to go shot-for-shot with the Bengals. This time around, an already-struggling Ravens secondary is without Marlon Humphrey and the offense is stuck with either backup Tyler Huntley or a less-than-100% Lamar Jackson. The key in this matchup is explosive passing. Thanks to Burrow's aggressiveness and the individual talent of the Bengals' wide receivers, they have been able to brute force a ton of explosive passes throughout the season. Some of them may have been lucky (like the Darnell Savage near-INT), but the Bengals keep finding a way, fortunate or not. The Ravens defense, on the other hand, has the second-worst rate of explosive passing plays allowed in the NFL. Only the Jets are worse. Burrow exposed this matchup for 416 yards and three touchdowns the last time around. While the 400-plus yard aspect of that may be a little rich and unrepeatable, clearing the 280-yard mark and hoping that Burrow gets plenty of opportunities to finish drives in the end zone is plenty reasonable.

Article Author


You've seen his breakdowns and football analysis on Twitter and elsewhere. Now, Derrik Klassen brings his unmatched knowledge of the game to OddsChecker to give us his NFL picks each and every week.


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