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NFL Week 16 Picks: Three Bets You Should Make Right Now

It is about that time that we lock in our three best NFL bets for the week. We are coming fresh off a pair of big weeks, so let's keep up the momentum this weekend as I found three games I love to lock in.

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Arizona Cardinals vs. Indianapolis Colts Prediction

Cardinals vs Colts Odds

The first game I will dive into will be a battle between the playoff-hopeful Indianapolis Colts and the struggling Arizona Cardinals all of a sudden. The Cardinals are coming off back-to-back losses for the first time all season, shockingly losing to the Detroit Lions last weekend. The Colts are coming off perhaps their best win of the season, knocking off the red-hot New England Patriots. The Cardinals will look to bounce back on their home turf this week, and I believe they will do so. I will back the Cardinals on the money line this week as I think this is a perfect get-me-right bounce-back spot for the Cards. The play of Kyler Murray has been down the last few weeks, but this will be the spot he gets right against this Colts defense. The Colts run game has been one of the best in the league, but I think the Cardinals offense will force the Colts to play catch up and flip the game script into the Colts throwing the ball the majority of the second half, which will favor the Cardinals. I will gladly back the short home favorite here this week in this spot. 

Arizona Cardinals vs. Indianapolis Colts Pick

New England Patriots vs. Buffalo Bills Prediction

Patriots vs Bills Odds

The second play I am going with will be a massive battle between the Buffalo Bills and the New England Patriots. The Patriots went into the windy Bills stadium and knocked them off in one of the craziest games of the season that saw Mac Jones complete just one pass all game. The weather for this one will not be nearly as bad as it was in Buffalo and should follow more of a normal game script that will allow Josh Allen to throw the ball more often. The Play I am going with here will be the BIlls with the points on the spread at plus three. The golden rule for me is an evenly matched battle to take the points and run! The Bills are the better team to me despite what happened in New England, and this will be the perfect revenge spot for the Bills. The Bills will have revenge on their minds, and I think that Sean Mcdermott will have a good enough game plan to force the Patriots to throw the ball and not be able to run as much as they did last game. This is the perfect spot to back the Bills as the dog. I think they do win this game outright but will be safe and take the points.

Patriots vs. Bills Pick

Las Vegas Raiders vs. Denver Broncos Prediction

Raiders vs Broncos Odds

The final play I am going with will be an AFC West showdown between the Denver Broncos and the Las Vegas Raiders. Last week, the Raiders saw themselves land a massive win over the Browns on a Dylan Carlson game-winning field goal. The Raiders put themselves right back into the playoff picture with that win and will look to continue their winning ways this weekend at home. I will back the Raiders here, who I feel are the better team at home and the healthier team overall. The run game for the Raiders will have to show up and allow Derek Carr to do his thing in the passing game. I have been more impressed with the Play of Carr the last few weeks, and I think this Raiders defense will do a good enough job against this Broncos offense who struggles to make things happen. Teddy Bridgewater's status has also been up and down all season, and I can not trust him on the road in a divisional game. 

Raiders vs. Broncos Pick

Article Author


Matt McCuen is a native of Delco, PA. He has been working in the sports gambling industry and creating content for the last few years. He is an expert in numerous different sports, including the NFL, NBA, MLB, NHL, and collegiate sports. You can follow Matt on Twitter at @DeadPresPicks.


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