Share to Facebook
Share to Twitter
Copy Link
Arizona Cardinals vs. Indianapolis Colts best bet and prediction by NFL handicapper LightningLockz for the Week 16 matchup coming on Christmas night.

Arizona Cardinals vs. Indianapolis Colts Top Bet: Bank on Arizona Christmas Night

Another excellent TV game tonight as we have two teams fighting for the playoffs in the desert of Arizona tonight. This game feels like a "what have you done lately for me" game. Sure the Colts just proved themselves and beat the Patriots, but the win didn't impress us as the Patriots played awful for three quarters, and in the fourth, we had a ball game until Jonathan Taylor busted one to ice it.

Arizona Cardinals vs. Indianapolis Colts Start Time, Where to Watch, and Odds

Date: Saturday, December 25, 2021

Game Time: 8:15 pm ET

Where to Watch: NFL Network

Click Here For Cardinals vs Colts Odds

DraftKings logo
Bet $5, Get $150 if your team wins on Christmas Day
  • Christmas Day Exclusive
  • Get 30/1 odds on any team
  • Best odds boost on the market

Claim Now
New Customers OnlyT&Cs
Caesars Sportsbook logo
Bet $10 Get $100 If Your NFL Team Scores on Christmas Day
  • Get $100 if your NFL/NBA team scores A POINT
  • Plus Bet $100, Get an NBA Jersey
  • Promo Code ODDSHOLIDAY

Claim Now
New Customers OnlyT&Cs
Fanduel logo
Bet $5, Win $150 CASH on any NFL team this Christmas
  • Bet $5, Get $150 cash on any team
  • Christmas Exclusive
  • Limited time offer

Claim Now
New Customers OnlyT&Cs
BetMGM logo
Bet $10, Win $200 If There's A 3-Pointer
  • Deposit $10 into your new BetMGM account
  • Bet $10 on any NBA Moneyline
  • Get $200 if your team scores a three

Claim Your $200 Now
New Customers OnlyT&Cs

Cardinals vs. Colts Prediction

It's not often Big Bad Bill is questioned about his choices, but he kicked a field goal instead of going for it down 13, making it ten which is still two scores. That play might have cost him, but either way, the Colts were dominating for three quarters. In our eyes, they barely pulled it out, making that win far less impressive. The Colts only had 15 first downs, and in a role reversal, they threw for 49 yards the week after the Patriots threw for a season-worst 19 yards. Turnovers are always a key, and Mac Jone's two interceptions cost them the game. People are high on the Colts, but we still feel they are a one-trick pony.

On the other side of the ball, we have Arizona, who embarrassed themselves last week. The Lions are playing better but missing their two best offensive players blew out Arizona. The game was never in doubt. It was probably the most shocking score we have seen this season. Arizona was down from their loss to the Rams and lacked motivation after slipping from the number one seed they were in all year, losing to the Rams. Then they followed it up with a true stinker in Detroit. There is no excuse for that performance, and the Cardinals have to get back on track today because the schedule doesn't get easier with the Cowboys and divisional rival Seahawks coming up.

The Cardinals still have a division title, a playoff bye all in front of them, and we feel they got that stinker out of the way, and they will rise today and win a game that they desperately need.

Why do we like Arizona today? First off, nowadays, you always have to check COVID and injuries. With Offensive Guard Quentin Nelson out today, he is a massive loss for the Colts as he is the main reason those holes have been there for Taylor to run through. The Cardinals are one of the best run defenses in the league. This is a huge loss that will be very noticeable today. They are also missing Mark Glowinski (COVID) and Center Ryan Kelly (family issues), meaning that the whole offensive line will look different today.

Arizona is a top 10 defense and very good against the run usually, giving up less than 113 yards a game. Arizona can load up the line against the replacement offensive line without the fear of Wentz and the receivers and should dominate this game in the trenches. We also have mentioned before that the Colts record is excellent, but they recently beat the Texans, Jets, and Jaguars, and we are not high on them.

While Arizona had their letdown, they have spoken all week about how they were down and tried to hit that full-court shot instead of working it down low and taking the bucket using a basketball analogy. We expect Arizona to come out and establish the run with Edmonds back and Conner healthy and let their defense dominate the backups on the offensive line. We feel Markus Golden and Chandler Jones woke up chomping at the bits on Christmas day, finding out they will be going after backups.

Take the soft number today with the embarrassed Cardinals as they get back on track and get a 7-10 point win tonight in the desert.

Cardinals vs. Colts Pick

  • Arizona Cardinals -2 (-115)
Bet $20, Get $100 in Virginia
  • Bet $20, Get $100 on Any Sport
  • Promo Code GET100
  • Virginia Sports Betting Exclusive

Claim Your $100 Now
Bet $20, Get $100 on Any Sport
  • Bet $20, Get $100 on Any Sport
  • Promo Code GET100
  • Sports Illustrated Exclusive

Claim Your $100 Now
Caesars Sportsbook logo
Wager up to $1,250 and Get Your Stakes Back if You Lose
  • Use Promo Code OCUS1FULL
  • Get Your Stakes Back if You Lose up to $1,250
  • Get 1,000 Reward Credits® and 1,000 Tier Credits

Claim Now
New Customers OnlyT&Cs

Article Author

ROI 43.4%

Need a pick for the NFL, NBA, NHL, NCAAB, or basically any other sport? Lightning Locks has you covered with a history of accurate picks for each sport.

Expert Handicappers

View all Handicappers

Almost there!

We are loading your bets, and they will be here in a second.