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Arizona Cardinals vs. Los Angeles Rams prediction and pick for the opening round of the 2022 NFL Playoffs. The NFL Postseason is finally here. We get it kicked off by getting handicapper Jason Radowitz's picks for this NFC West matchup.

Arizona Cardinals vs Los Angeles Rams Prediction: Can Matthew Stafford Limit The Interceptions?

The Los Angeles Rams are going all in this season. The Rams signed Von Miller and Odell Beckham Jr. during the season and brought in Matthew Stafford prior to the season starting. Clearly, the Rams believe they're in a position to win the Super Bowl this year. But recently, Stafford and the Rams haven't played all that well. Despite the Rams winning four of their last five, Los Angeles won each game by 10 or fewer points.

Is this something to be concerned about going into Monday's contest against the Arizona Cardinals? Here are our picks and predictions for the NFC Wild Card matchup between the Cardinals and Rams.

Arizona Cardinals vs. Los Angeles Rams Start Time, Where to Watch, and Odds

Date: Monday, January 17, 2022

Game Time: 8:15 p.m. ET

Where To Watch: ABC/ESPN

Click here for Cardinals vs. Rams odds

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Cardinals vs. Rams INJURY REPORT


Questionable: WR Rondale Moore (Ankle), DE J.J. Watt (Shoulder), CB Marco Wilson (Shoulder), DE Jordan Phillips (Knee), RB Chase Edmonds (Ribs) Out: WR DeAndre Hopkins (Knee)


Questionable: S Taylor Rapp (Concussion) Out: RB Darrell Henderson Jr. (Knee)

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Arizona Cardinals vs Los Angeles Rams Betting Line Movement

Arizona Cardinals vs. Los Angeles Rams Prediction

In two games this season, the Cardinals and Rams each won one game. On Monday, it'll be the rubber match of a three-game series. This game is the most important as the winner will advance in the playoffs while the other goes home. On paper, the Rams are the much better team. Offensively, the Rams have been more consistent behind Matthew Stafford, who has thrown for 41 touchdowns on the season. The Rams will have Sony Michel and also will likely have Cam Akers at running back to add a little bit of spice to the backfield. Meanwhile, Stafford's connection with Cooper Kupp and the other receivers has truly been remarkable this year. With Tyler Higbee back along with Van Jefferson and Odell Backham Jr., the Rams' offense is just very intriguing. However, Stafford has thrown 17 interceptions this season. That's about one interception per game. It's also pretty unacceptable, especially going into the playoffs. Stafford can be really great at times but he can also really make some poor decisions that could cost his team. To be fair, the Cardinals really haven't been that great in the secondary this year but the pass rush, especially if J.J. Watt is back, could get to him and force him into a mistake or two. The Cardinals have been terrible defending against the run and have missed so many tackles this season. The Rams should be just fine offensively. On the other hand, the Cardinals have been just as good on the offensive end, with Kyler Murray back. The pass protection and run blocking aren't getting the job done for the Cardinals, but luckily, Murray can scramble around and make plays happen regardless. While the Rams have missed many tackles this year, the coverage has improved as the season has progressed. On top of that, the front seven has been dominant all year, no matter who is on the field. The Rams held the Cardinals to 23 points on December 13 in a 30-23 win. However, on October 3, the Cardinals won 37-20 and destroyed the Rams in the running game, earning 216 yards on the ground. The Rams were much better the second time around defending the run. Therefore, I'll take my chance with the Rams -4.5.

Arizona Cardinals vs. Los Angeles Rams Pick

  • PICK: Rams -4.5 (-110)
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Article Author


Jason grew up an avid sports fan. His passion for sports writing grew in high school and he developed a blog that was strictly for New York Sports. From his work, you will quickly realize that he loves looking at games from an analytical and numbers perspective and hopes to provide you with that same perspective in his articles.

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