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The Indianapolis Colts (2-2-1) will host the Jacksonville Jaguars (2-3) on Sunday afternoon at Lucas Oil Stadium in Indianapolis, Indiana at 1 p.m. ET. NFL handicapper Matt MacKay is here with his Colts vs. Jaguars prediction.

Indianapolis Colts vs. Jacksonville Jaguars Prediction, Pick, Odds: Will the Colts Get Revenge?

It's a revenge game rematch between two AFC South opponents in Week 6. Jacksonville completely dominated the first matchup in front of its home crowd, forcing Matt Ryan to throw three interceptions, while holding star running back Jonathan Taylor to 63 scrimmage yards. The Colts hardly had any time to sustain drives on offense, finishing with under 22 minutes of the time of possession.

The Jaguars started the season with great offensive performances, scoring at least 22 points and jumping to a 2-1 record. This included an impressive 38-10 win against the Los Angeles Chargers in SoFi Stadium following their shutout of Indianapolis. Head coach Doug Pederson has rekindled Jacksonville's organization with significant personnel development and good play-calling. The defense has been the true surprise, holding opponents to an average of 16 points per game.

Will the Colts be able to even the series with a win at home in Week 6? Or will the Jaguars' defense continue to hold Indianapolis' offense down? Here are our picks, predictions, and odds for Sunday's game in Indianapolis between the Indianapolis Colts vs. Jacksonville Jaguars.

Indianapolis Colts vs. Jacksonville Jaguars Start Time, Where to Watch, and Odds

  • Date: Sunday, October 16
  • Game Time: 1:00 p.m. ET
  • Where to Watch: CBS

Colts vs. Jaguars Odds

  • Spread: Indianapolis -2 (-110), Jacksonville +2 (-110)
  • Total Odds: Over/Under 42 (-110)
  • Moneyline: Indianapolis (-130), Jacksonville (+110)

Click here for Colts vs. Jaguars odds

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Colts vs. Jaguars Injury Report


Probable: G Quenton Nelson (Ankle)

Questionable: RB Phillip Lindsay (Undisclosed), DE Kwity Paye (Ankle), S Julian Blackmon (Ankle), RB Jonathan Taylor (Ankle), RB Nyheim Hines (Concussion), LB Shaq Leonard (Concussion)


Questionable: DE Folorunso Fatukasi (Quad), WR Zay Jones (Ankle), NT DaVon Hamilton (Foot), LB Foyesade Oluokun (Calf)

Indianapolis Colts vs. Jacksonville Jaguars Prediction

Recent history tells us that the Jaguars dominate the Colts when they play them at home. The previous two matchups between these two AFC South teams have both been held at TIAA Bank Field in Jacksonville, where Jacksonville has outscored Indianapolis 50-11. This includes the shoutout earlier this season, as well as the disappointing 26-11 loss in Week 18 that cost the Colts a playoff berth with former quarterback Carson Wentz.

In Week 6, the Colts will get the benefit of returning home after outlasting Denver 12-9 in an overtime win on Thursday Night Football in Week 5. Indianapolis has won both of their previous home games against Jacksonville, finishing 23-17 in 2021 and 28-14 in 2020. It's an important stat to take into account, as the Colts fall apart whenever they play the Jaguars on the road.

Matt Ryan is not the only player to blame for the lackluster outing in Week 2. Yes, he completed 16 of 30 pass attempts for 195 yards and three interceptions, but the leader in total yards was wideout Ashton Dulin, who is now out indefinitely with a foot injury. To make matters worse, their running back depth is being tested, as Jonathan Taylor, Nyheim Hines, and Phillip Lindsay are all questionable with various injuries. If Taylor can suit up and overcome his ankle injury, he's poised to make a significant impact, as he handled 21 carries for 116 yards and a touchdown the last time these two teams played at Lucas Oil Stadium. If none of these running backs can give it a go, second-year running back Deon Jackson will be the RB1.

Both teams are 2-3 ATS this season. A two-point spread indicates that oddsmakers believe this matchup will be closely contested until the final whistle. Since it's being played in Indianapolis, the Colts are laying two points as the betting favorite. The Colts' passing game is surprisingly ranked 14th in the league, thanks to the rapport rookie wideout Alec Pierce is establishing with Ryan. Michael Pittman Jr. remains the alpha target on the perimeter, while tight end Mo Alie-Cox, Jelani Woods, and Kylen Granson form a quality tandem for blocking and receiving production.

Jacksonville's run defense is sixth-best in the league, while the pass defense remains ranked inside the top 15. The Jaguars don't generate much pressure though, averaging only two sacks per game. The Colts' offensive line is expected to have All-Pro guard Quenton Nelson in the lineup on Sunday, which will be immensely helpful to protect Ryan and give him some time to set his feet to complete passes. Let's also give credit to Indianapolis' defense, which is only bad at forcing turnovers. Every other aspect of their defense is solid, as they allow only 18.8 points per game and shut down opposing running backs.

The home team in this series has won each of the last ten games, while Jacksonville has been unable to cover the spread in six of their past seven road games. This is enough for me to invest in the Colts extending their winning streak and beating the Jaguars by two or more points at home in Week 6.

Indianapolis Colts vs. Jacksonville Jaguars Pick

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Article Author


Matt is an avid writer, editor, and researcher. He enjoys analyzing the game within the game which is fantasy sports and sports betting. Music is another constant in his daily life. Matt loves spending time with his wife and three pets. He likes to read, listen to podcasts, and is constantly motivated to create the most accurate and engaging content in the sports betting industry.


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