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The Chiefs lost a very hard-fought game last weekend to the Bills and now face an even tougher matchup here against the 49ers. Joey Ruiz breaks down this Sunday's Week 7 afternoon matchup.

San Francisco 49ers vs. Kansas City Chiefs Prediction, Pick Against the Spread, and Latest Odds

49ers vs. Chiefs Start Time, Where to Watch, and Odds

  • Date: October 23, 2022
  • Game Time:4:25 pm ET
  • Where to Watch: FOX

49ers vs. Chiefs Odds

  • Moneyline: Chiefs (-115), 49ers (+105)
  • Spread: Chiefs -1 (-110), 49ers +1 (-105)
  • Total: Over/Under 49 (-110)

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San Francisco 49ers vs. Kansas City Chiefs Prediction

The Chiefs don't lose too often, but when they do, they usually bounce back. One thing that is very interesting to me about this game is how it is lined. The 49ers have an excellent defense and one of the best pass rushes in the league and are getting multiple key players back from injury, and yet, they are still home underdogs. In my opinion, this is showing a ton of strength toward the Chiefs.

Kansas City has also played excellent on the road this season, particularly in the first half of those games. KC has yet to trail at the half on the road this year as they led TB by 11, led Indy by 4, and led Arizona by 16. I fully think Mahomes and this high-powered offense will bounce back this afternoon, and I do not fully trust Jimmy G to move the ball and put the ball into the end zone against a bend but don't break Kansas City defense. That said, I am rolling with the CHIEFS 1H ML at -108 and FULL GAME ML at -112 for 1U each as one of my most confident NFL plays of the day.

49ers vs. Chiefs Picks

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Article Author


Joey has spent the last 6+ years betting on sports with a focus on basketball and baseball. Basketball is his main focus, and not many people know more about mid-major basketball than him. Whether you need advice on a Saturday night primetime game or a Tuesday night back-alley SWAC/MEAC game, Joey is your man.


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