Man Utd vs Roma Lineups, Prediction, Betting Picks & Odds

Man Utd vs Roma Game Preview

Man Utd host Roma at Old Trafford in the Champions League on Tuesday, and any Man Utd vs Roma prediction starts with a home side desperate for something resembling a result.

Michael Carrick's side are winless in nine games across all competitions. Saturday's loss at Chelsea only turned up the heat on a squad running short of answers.

Roma arrive in far better shape, unbeaten in 17 Serie A games under Gian Piero Gasperini and pressing with an aggression that makes them awkward to play through.

History favors the hosts. Man Utd have won their last five home games against Roma in all competitions, and that record gives a fragile squad something to cling to.

Man Utd vs Roma Recent Results

Man Utd's slump runs deep. Domestically, they were beaten 2-0 at Chelsea on Saturday, and the Premier League standings make for grim reading. Europe offers no relief either, after a 4-1 hammering at Como in their last Champions League outing. Bruno Fernandes is still the heartbeat, leading the press from the front, but the defense keeps leaking.

Roma are flying in Serie A, and they scored four before halftime in a rout of Udinese at the weekend. Their Champions League campaign finally clicked with a 4-0 home win over Slovan Bratislava. Donyell Malen has been their standout attacker in the competition, constantly arriving in the box and giving Roma a cutting edge up top.

Man Utd vs Roma Lineups & Team News

Injuries & Suspensions

Man Utd: Patrick Dorgu (Injured/out), Benjamin Šeško (Injured/out), Manuel Ugarte (Injured/out), Luke Shaw (Injured/out), Marcus Rashford (Injured/out), Amad Diallo (Suspended)

Roma: Manu Koné (Injured/out), Lorenzo Pellegrini (Injured/out), Mile Svilar (Injured/out), Paulo Dybala (Injured/doubtful)

Man Utd

The probable Man Utd vs Roma lineups show how thin United's attack has become, with Benjamin Šeško and Marcus Rashford both out and Amad Diallo also missing. Bruno Fernandes leads the line in the projected setup, with Youri Tielemans behind him. The bigger worry is at the back, where United have conceded 13 goals in their last six games in all competitions.

Roma

Mile Svilar is out, so Pierluigi Gollini deputizes in goal behind a back three anchored by Gianluca Mancini. Lorenzo Pellegrini and Manu Koné are sidelined, while Paulo Dybala is doubtful. Roma still have plenty of firepower, though, and Donyell Malen is the man United must track all night.

Man Utd vs Roma Predicted Lineup

Man Utd

Formation: 4-2-3-1 (probable)

Predicted Starting Lineup: Senne Lammens; Diogo Dalot, Leny Yoro, Harry Maguire, Noussair Mazraoui; Kobbie Mainoo, Carlos Baleba; Bryan Mbeumo, Youri Tielemans, Matheus Cunha; Bruno Fernandes

Roma

Formation: 3-4-2-1 (probable)

Predicted Starting Lineup: Pierluigi Gollini; Gianluca Mancini, Evan Ndicka, Mario Hermoso; Nahuel Molina, Bryan Cristante, Marten de Roon, Wesley; Matías Soulé, Rodrigo Mora; Donyell Malen

Man Utd vs Roma Key Stats & Game Facts

• There have been 9+ shots on target in 3 of Man Utd's last 3 games in the Champions League.
• Donyell Malen has scored or assisted in 3 of his last 3 appearances in the Champions League.

Man Utd vs Roma Prediction & Best Picks

Our Prediction

Our prediction is Man Utd edging a messy, open game at Old Trafford. Roma bring the better form, but their defense has been a soft touch on the road in Europe, and United's home record in this competition is still a real weapon. Our numbers make the hosts slight favorites with a 41.96% implied probability of winning, so this is no stroll, and it shapes our Man Utd vs Roma best picks below: back the goals, not a shutout.

Best Picks

Over 3.5 goals in the Total Goals Over/Under market. Two open, attack-minded sides and a leaky Man Utd defense point to a high-scoring night at Old Trafford. The Total Goals Over/Under market is where we want to be. Our projections put this game at 3.57 total goals, which is a strong signal for the over. United have also conceded 13 goals in their last six games in all competitions, and Roma have the attacking quality to cash in.

Both Teams To Score: Yes. Man Utd and Roma have both scored in recent meetings, and both sides carry goal threat despite injuries. Both Teams To Score is the natural partner to the high total. Our projections land at 69.14% for both sides finding the net. Fernandes and Malen give each team a reliable outlet, and neither back line has earned much trust.

Man Utd vs Roma Same Game Parlay

Our Man Utd vs Roma same game parlay picks back the hosts on the Moneyline, Donyell Malen to score, Both Teams To Score and a card for Mario Hermoso.

Man Utd on the Moneyline at +125 (TonyBet) leans on Old Trafford. They have won their last five home games against Roma in all competitions.

Donyell Malen in the Anytime Goalscorer market is the obvious Roma angle. He has scored in 2 of his last 3 appearances in the Champions League.

Both Teams To Score: Yes fits the history. Roma have scored at least two goals in their last three games against Man Utd in all competitions, and United have done the same.

Mario Hermoso in the To Be Shown A Card market rounds it off. Roma press high and aggressively, and Hermoso faces a long night dealing with a busy United attack.

Make sure to get the best odds on your Same Game Parlay with Oddschecker's Exclusive Same Game Parlay Comparison Tool.

Same Game Parlay odds correct at time of publishing.

Man Utd vs Roma Talking Points

Omar Berrada and Jason Wilcox have handed Michael Carrick another night in the dugout, but this feels like a referendum on his tenure. The bigger betting story is Roma on the road: they have gone 32 straight away games in the competition without a clean sheet. Set that against United's run of seven straight home wins in UEFA competition, and the goals markets in the Man Utd vs Roma betting odds deserve a long look. Jesús Gil Manzano takes charge, and Roma's aggressive press could keep him busy.

Man Utd vs Roma Predictions FAQs

When is the Man Utd vs Roma Champions League game?

The game kicks off at 3:00 PM ET / 12:00 PM PT on Tuesday, November 3, 2026.

Where is Man Utd vs Roma being played?

The game is being played at Old Trafford in Manchester.

Who is probably starting for Man Utd against Roma?

Man Utd are projected to line up in a 4-2-3-1 formation, with Senne Lammens in goal and Bruno Fernandes as the central forward in the projected lineup.

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