Crystal Palace vs TSG Hoffenheim Lineups, Prediction, Betting Picks & Odds

Crystal Palace vs TSG Hoffenheim Game Preview

Crystal Palace host TSG Hoffenheim at Selhurst Park on Thursday in the Europa League, and both clubs are desperate to turn the page on rough domestic weeks.

Palace are 15th in the Europa League standings, but Pierre Sage's side sit in the Premier League relegation zone. They have lost four of their last six competitive games.

Hoffenheim sit 23rd in the Europa League standings. Christian Ilzer's side only got their campaign moving by flattening Lyon, and last season's top-six Bundesliga finish shows the talent is there.

Crystal Palace vs TSG Hoffenheim betting odds have Palace as -110 (Polymarket) favorites. Hoffenheim sit at +300 (Polymarket), and Palace badly need a result to stop the bleeding.

Crystal Palace vs TSG Hoffenheim Recent Results

Palace come in off a 2-0 loss to Tottenham Hotspur, the latest blow in an ugly October. Selhurst Park on European nights is a different world, with Palace unbeaten in their last seven continental games there. Yéremy Pino has been the standout, sitting among the Europa League's joint-leading scorers, and Jean-Philippe Mateta also scored at Beşiktaş.

Hoffenheim arrive on a domestic skid, a DFB-Pokal penalty shootout exit followed by a Bundesliga loss. That ended a winning run that featured a 3-0 Europa League rout of Lyon, with Adam Hložek and Andrej Kramarić on target. The problem is the road, where they have won just one of their last six European away games.

Crystal Palace vs TSG Hoffenheim Lineups & Team News

Injuries & Suspensions

Crystal Palace: Takehiro Tomiyasu (Injured/out), Ismaïla Sarr (Injured/out), Chadi Riad (Injured/out)

TSG Hoffenheim: Patrick Wimmer (Injured/out), Nathan De Cat (Injured/out), Robin Hranáč (Injured/out), Vladimír Coufal (Injured/out), Valentin Gendrey (Injured/out), Bambasé Conté (Injured/out), Albian Hajdari (Injured/out)

Crystal Palace

Pierre Sage loses Ismaïla Sarr from his attack, while Chadi Riad and Takehiro Tomiyasu remain out in defense, but Palace came through the weekend without fresh concerns. As for Crystal Palace vs TSG Hoffenheim lineups, Palace should have Dean Henderson behind a back three of Jaydee Canvot, Axel Disasi and Chris Richards, with Óscar Mingueza and Tyrick Mitchell at wing-back. Adam Wharton and Daichi Kamada run the midfield, and Yéremy Pino and Dwight McNeil support Jean-Philippe Mateta. Goals have been the issue lately, with just five in their last six competitive games.

TSG Hoffenheim

Christian Ilzer is without seven injured players, and the damage is heaviest in defense. Oliver Baumann should start behind Natnael Abraha, Ozan Kabak, Koki Machida and Mats Rots. Andrej Kramarić, Wouter Burger, Leon Avdullahu and Adam Daghim form the midfield four, with Adam Hložek and Fisnik Asllani up top. Hložek has had a hand in the club's last two away goals, with a goal and an assist.

Crystal Palace vs TSG Hoffenheim Predicted Lineup

Crystal Palace

Formation: 3-4-2-1 (probable)

Predicted Starting Lineup: Dean Henderson; Chris Richards, Axel Disasi, Jaydee Canvot; Óscar Mingueza, Adam Wharton, Daichi Kamada, Tyrick Mitchell; Yéremy Pino, Dwight McNeil; Jean-Philippe Mateta (probable)

TSG Hoffenheim

Formation: 4-4-2 (probable)

Predicted Starting Lineup: Oliver Baumann; Natnael Abraha, Ozan Kabak, Koki Machida, Mats Rots; Andrej Kramarić, Wouter Burger, Leon Avdullahu, Adam Daghim; Adam Hložek, Fisnik Asllani (probable)

Crystal Palace vs TSG Hoffenheim Key Stats & Game Facts

• There have been 29+ shots taken in 3 of Hoffenheim's last 3 games in the Europa League.
• Hoffenheim have received 3+ cards in 3 of their last 3 games in the Europa League.
• Yéremy Pino has scored in 3 of his last 3 appearances in the Europa League.
• Ozan Kabak has committed 3+ fouls in 3 of his last 3 appearances in the Europa League.
• Crystal Palace have scored 2+ goals in 3 of their last 3 games in the Europa League.

Crystal Palace vs TSG Hoffenheim Prediction & Best Picks

Our Prediction

Our Crystal Palace vs TSG Hoffenheim prediction is a Palace win in an open game where both teams score. Selhurst Park has been a different animal in Europe, and Palace have not conceded the opening goal in any of their last seven continental games there. Hoffenheim carry enough up top to get on the board, but not enough to knock over a home side that keeps setting the tone on European nights.

Best Picks

Crystal Palace to win in the Moneyline market. First up among our best picks, we back the hosts outright in the Moneyline market. The projections make Palace roughly a 49% winner, well clear of the visitors. A Hoffenheim side that has won just one of its last six European away games is hard to trust away from home.

Both Teams To Score: Yes. The Both Teams To Score market is where two leaky defenses pay off. Palace have conceded 14 goals in their last six competitive games, and a Hoffenheim back line stripped by injuries is in no shape to keep Palace quiet. The projections put Yes at 62%, which fits our call of a Palace win with goals at both ends.

Crystal Palace vs TSG Hoffenheim Same Game Parlay

Our Crystal Palace vs TSG Hoffenheim Same Game Parlay picks pair a Yéremy Pino double with Over 3.5 Total Goals and a Hoffenheim cards line.

Yéremy Pino in the Anytime Goalscorer market is the anchor. He has scored in all three of his Europa League appearances this season, opening the scoring every time.

Over 3.5 in the Total Goals Over/Under market follows Palace's European pattern. Every one of their Europa League games this season has featured at least four goals.

Over 2.5 in the Total Away Team Cards market targets Hoffenheim's discipline. They have received 3+ cards in 3 of their last 3 Europa League games.

Pino in the To Be Shown A Card market rounds it out. He has been carded in 2 of his last 3 Europa League appearances, and that record is the basis for this leg.

Make sure to get the best odds on your Same Game Parlay with Oddschecker's Exclusive Same Game Parlay Comparison Tool.

Same Game Parlay odds correct at time of publishing.

Crystal Palace vs TSG Hoffenheim Talking Points

The biggest storyline is Yéremy Pino, who won this competition with Villarreal in 2021 and is now carrying Palace's European push. Palace have also never gone three straight European games without a win, so after back-to-back winless outings, an unwanted club record is on the line. Hoffenheim, meanwhile, are chasing consecutive European wins for the first time in years, and doing it at Selhurst Park is a tall ask.

Crystal Palace vs TSG Hoffenheim Predictions FAQs

When is the Crystal Palace vs TSG Hoffenheim Europa League game?

The game kicks off at 12:45 PM ET / 9:45 AM PT on Thursday, November 5, 2026.

Where is Crystal Palace vs TSG Hoffenheim being played?

The game is being played at Selhurst Park.

Which players are ruled out for Crystal Palace vs TSG Hoffenheim?

Crystal Palace are without Takehiro Tomiyasu, Ismaïla Sarr and Chadi Riad through injury. TSG Hoffenheim are missing Patrick Wimmer, Nathan De Cat, Robin Hranáč, Vladimír Coufal, Valentin Gendrey, Bambasé Conté and Albian Hajdari, all injured.

Which betting markets are listed for the Crystal Palace vs TSG Hoffenheim game?

Game odds are listed in the Moneyline, Total Goals Over/Under and Both Teams To Score markets.

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