Sassuolo vs Lazio Lineups, Prediction, Betting Picks & Odds
Sassuolo vs Lazio picks, probable lineups, injury news and Same Game Parlay ideas ahead of Tuesday's game. Check the odds and prediction before kick-off.
Cody Moore - October 27, 2026, 9:38 AM EDT
6 minutesSassuolo vs Lazio Game Preview
Competition | Italian Serie A |
|---|---|
Game Date | Tuesday, October 27, 2026 |
Game Time | 1:30 PM ET / 10:30 AM PT |
Venue (City, Stadium) | Reggio Emilia, MAPEI Stadium - Città del Tricolore |
Our Sassuolo vs Lazio prediction starts with the standings. Lazio arrive at MAPEI Stadium on Tuesday looking like a contender, while Sassuolo are still searching for a foothold in Serie A.
Sassuolo sit 14th in the standings and limp in off a 2-0 loss at Como. Alberto Aquilani's side carry plenty of attacking intent, but the back line keeps springing leaks.
Lazio sit second in Serie A after a 2-1 home win over Parma. Gennaro Gattuso's group attack down the wings with real menace and finish their chances with conviction.
The head-to-head points the same way. Lazio own four wins from the six previous meetings, with Sassuolo winning once and the remaining game ending in a tie.
Sassuolo vs Lazio Recent Results
Sassuolo's problem is at the back. They have conceded at least two goals in five of their last six Serie A games, which is no way to climb the standings. Vasilije Adzic is the bright spot, with a goal or assist in four of his last six Serie A appearances.
Lazio are rolling. They have won eight of their last nine Serie A games, and the attack is doing the heavy lifting. Mattia Zaccagni drives it from the left, with a goal or assist in four of his last six Serie A appearances.
Sassuolo vs Lazio Lineups & Team News
Injuries & Suspensions
Sassuolo: Fedde Leysen (Injured/out), Ismaël Koné (Injured/out), Jay Idzes (Injured/out), Daniel Boloca (Injured/out)
Lazio: Albert Gudmundsson (Injured/out), Adam Marusic (Injured/out), Andrea Pinamonti (Injured/out)
Sassuolo
Alberto Aquilani's probable 4-3-3 has Arijanet Muric in goal and Nemanja Matic anchoring the midfield. The attacking trio of Armand Laurienté, Sebastiano Esposito and Domenico Berardi carries the goal threat, while four injuries, including Jay Idzes and Ismaël Koné, strip depth from the squad.
Lazio
Gennaro Gattuso's probable 4-3-3 has Christos Mandas in goal and Davide Frattesi, Reda Belahyane and Kenneth Taylor running the midfield. Mattia Zaccagni and Gustav Isaksen work the flanks around Tijjani Noslin, with Andrea Pinamonti the most notable absence on the injury list.
Sassuolo vs Lazio Predicted Lineup
Sassuolo
Formation: 4-3-3
Predicted Starting Lineup: Arijanet Muric; Josh Doig, Cas Odenthal, Duje Caleta-Car, Simone Cinquegrano; Kristian Thorstvedt, Nemanja Matic, Vasilije Adzic; Armand Laurienté, Sebastiano Esposito, Domenico Berardi
Lazio
Formation: 4-3-3
Predicted Starting Lineup: Christos Mandas; Nuno Tavares, Oliver Provstgaard, Josip Sutalo, Romano Floriani Mussolini; Davide Frattesi, Reda Belahyane, Kenneth Taylor; Mattia Zaccagni, Tijjani Noslin, Gustav Isaksen
Sassuolo vs Lazio Key Stats & Game Facts
- Lazio have received 3+ cards in 5 of their last 6 games vs Sassuolo (Serie A).
- Sassuolo have seen under 2.5 goals in their last 3 home games against Lazio in all competitions.
- There have been 11+ shots on target in 6 of Sassuolo's last 8 games (Serie A).
- Gustav Isaksen has attempted 3+ shots in 3 of his last 3 appearances (Serie A).
- Domenico Berardi has won 2+ fouls in 5 of his last 6 appearances vs Lazio (Serie A).
Sassuolo vs Lazio Prediction & Best Picks
Our Prediction
Our prediction is a 2-1 Lazio win. The Sassuolo vs Lazio betting odds have the visitors as favorites at +120 (Polymarket), and that feels right. Lazio control games in the opposition half and hammer the flanks, which is exactly where this Sassuolo defense struggles. The home side have enough shooters to find the net, but Lazio's finishing is the difference.
Best Picks
Lazio to win at Sassuolo on the Moneyline. Top of our Sassuolo vs Lazio best picks is a straight Moneyline play on the better team. The projections make Lazio clear favorites, the expected-value feed flagged the away win as well, and this is a sensible mid-range price rather than a short odds-on tag. Lazio's moneyline would have landed in 8 of the last 10 games against all opponents.
Over 2.5 goals in the Total Goals Over/Under market. Goals at both ends fit this matchup, and the projections land on a total north of three. There have been over 2.5 goals in 5 of Lazio's last 6 Serie A games. Add a leaky Sassuolo back line and the over is the right side of the Total Goals Over/Under market.
Sassuolo vs Lazio Same Game Parlay
Our Sassuolo vs Lazio same game parlay picks stack Lazio Over 1.5 Total Away Goals with two Mattia Zaccagni shooting props and Vasilije Adzic to score anytime.
Lazio Over 1.5 Total Away Goals: Lazio have scored 2+ goals in 6 of their last 6 Serie A games, and this Sassuolo defense gives them no reason to stop.
Mattia Zaccagni Over 2.5 Player Shots: the winger gets forward relentlessly, attempting 3+ shots in 6 of his last 8 Serie A outings and 2+ shots in 7 of 9 career appearances against Sassuolo.
Vasilije Adzic Anytime Goalscorer: Sassuolo's midfielder has found the net in 3 of his past 5 Serie A outings, making him the home side's in-form threat.
Mattia Zaccagni Over 0.5 Player Shots On Target: the winger is putting shots on frame in 5 of his past 6 Serie A outings, and he has done so in every one of his 4 career appearances against Sassuolo.
Make sure to get the best odds on your Same Game Parlay with Oddschecker's Exclusive Same Game Parlay Comparison Tool.
Same Game Parlay odds correct at time of publishing.
Sassuolo vs Lazio Talking Points
Gennaro Gattuso is not buying the hype. After the Parma win, he said his squad "frankly don't really belong up there" among the Serie A leaders and demanded his players keep the intensity high. That edge matters against a Sassuolo side rebuilding under Alberto Aquilani, who took charge in June 2026 after previously playing for the club. Kenneth Taylor, who opened the scoring against Parma, adds goal threat from midfield, but the real matchup is Lazio's left-sided attack against a home defense that struggles with attacks down the wings.
Sassuolo vs Lazio Predictions FAQs
When is the Sassuolo vs Lazio Italian Serie A game?
The game kicks off at 1:30 PM ET / 10:30 AM PT on Tuesday.
Where is Sassuolo vs Lazio being played?
The game is being played at MAPEI Stadium - Città del Tricolore.
Who is expected to start for Sassuolo and Lazio?
Both sides are projected to line up in a 4-3-3. Sassuolo's probable starters include A. Muric, D. Berardi and S. Esposito, while Lazio's include C. Mandas, M. Zaccagni and T. Noslin. Sassuolo are without F. Leysen, I. Koné, J. Idzes and D. Boloca, and Lazio without A. Gudmundsson, A. Marusic and A. Pinamonti.
Which betting markets are available for Sassuolo vs Lazio?
The listed markets for this Serie A game are the Moneyline, Both Teams To Score and Total Goals Over/Under.
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