Roma vs Sassuolo Lineups, Prediction, Betting Picks & Odds

Roma vs Sassuolo Game Preview

Roma host Sassuolo at the Stadio Olimpico, and the Roma vs Sassuolo betting odds tell a lopsided story, with the hosts installed as clear moneyline favorites.

Gian Piero Gasperini's side sit third in the standings and own the league's best attack with 28 goals, even with Paulo Dybala and Lorenzo Pellegrini among a stack of injuries.

Sassuolo sit 17th, hovering just above the relegation zone, and Alberto Aquilani's side have shipped more goals than anyone in the league, with 26 conceded.

History offers the visitors no comfort either. Across their last 24 games against Sassuolo in all competitions, Roma have gone unbeaten 22 times.

Roma vs Sassuolo Recent Results

Roma's attack is in full flow after a 5-2 rout at Udinese that was settled by halftime. The Champions League trip to Old Trafford stung, though, as they let an early lead slip and lost 3-2 to Manchester United. Matías Soulé keeps testing goalkeepers, but the back line has been leaking too much lately.

Sassuolo are in a full-blown slump. The 4-2 home loss to Fiorentina was their fourth straight Serie A defeat, and Armand Laurienté found the net in a game where the defense let him down again. Laurienté is the main bright spot, but this group can't keep anyone out right now.

Roma vs Sassuolo Lineups & Team News

Injuries & Suspensions

Roma: Paulo Dybala (Injured/out), Manu Koné (Injured/out), Lorenzo Pellegrini (Injured/out), Mile Svilar (Injured/out)

Sassuolo: Fedde Leysen (Injured/out), Daniel Boloca (Injured/doubtful), Ismaël Koné (Injured/doubtful)

Roma

The Roma vs Sassuolo lineups start with a patched-up home side. Gian Piero Gasperini sticks with his 3-4-2-1, and Pierluigi Gollini goes in goal with Mile Svilar injured. Matías Soulé and Rodrigo Mora sit behind Donyell Malen, but losing Paulo Dybala and Lorenzo Pellegrini takes serious creativity out of this attack.

Sassuolo

Alberto Aquilani goes with an attacking 4-3-3. Veteran Nemanja Matić anchors the midfield, while Armand Laurienté and Domenico Berardi flank Sebastiano Esposito up front. Defender Fedde Leysen is out, and midfielders Daniel Boloca and Ismaël Koné are doubtful, which leaves thin depth behind Matić.

Roma vs Sassuolo Predicted Lineup

Roma

Formation: 3-4-2-1 (probable)

Predicted Starting Lineup: Pierluigi Gollini; Mario Hermoso, Leonardo Balerdi, Daniele Ghilardi; Wesley, Niccolò Pisilli, Bryan Cristante, Emanuele Lulli; Matías Soulé, Rodrigo Mora; Donyell Malen (probable XI)

Sassuolo

Formation: 4-3-3 (probable)

Predicted Starting Lineup: Stefano Turati; Simone Cinquegrano, Duje Ćaleta-Car, Cas Odenthal, Josh Doig; Darryl Bakola, Nemanja Matić, Kristian Thorstvedt; Domenico Berardi, Sebastiano Esposito, Armand Laurienté (probable XI)

Roma vs Sassuolo Key Stats & Game Facts

• Roma have scored 2+ goals in 6 out of 9 games vs Sassuolo (Serie A).
• There have been 12+ shots on target in 3 of Roma's last 3 games (Serie A).
• Domenico Berardi has attempted 3+ shots in 6 of his last 10 appearances vs Roma (Serie A).
• Sassuolo have received 2+ cards in 6 of their last 7 games vs Roma (Serie A).
• Donyell Malen has scored or assisted in 3 of his last 3 appearances (Serie A).

Roma vs Sassuolo Prediction & Best Picks

Our Prediction

Our Roma vs Sassuolo prediction is a Roma win in a wide-open game. The hosts do their best work attacking down the wings, which is exactly where Sassuolo's back four comes apart, so Donyell Malen and Matías Soulé are set up for a big night. The catch is Roma's own defense, which lets opponents create too much, and Sassuolo have the counterattacking skill to make them pay. Our projection has Roma averaging 2.66 goals. Sassuolo still get on the board at 1.11.

Best Picks

Both Teams To Score: Yes. Roma and Sassuolo both find the net. This first of our Roma vs Sassuolo best picks sits in the Both Teams To Score market. Our numbers put both teams scoring at 62.35%, and that tracks. Roma's back line has been breached at least twice in each of its last 3 league outings in Serie A, and Sassuolo's counterattack has enough individual skill to punish a defense that open.

Total Goals Over/Under: Over 3.5 goals in the match. This one lives in the Total Goals Over/Under market. Our projection lands on 3.77 total goals, which puts Over 3.5 above the implied probability of its price for a modest value edge. Sassuolo's Serie A games keep turning messy too, with eight of the last 10 clearing 2.5 goals.

Roma vs Sassuolo Same Game Parlay

Our Roma vs Sassuolo same game parlay picks ride the Roma attack, stacking two Donyell Malen shot props with a big Roma goal total and a Paulo Dybala scorer leg.

Donyell Malen Over 1.5 in the Player Shots market. He has attempted 2+ shots in all 9 of his latest Serie A outings, and this Sassuolo defense will give him plenty of looks.

Donyell Malen Over 0.5 in the Player Shots On Target market. He has landed at least one shot on target 8 times across his most recent 9 league appearances in Serie A.

Roma Over 2.5 in the Total Home Goals market. Roma have put 3+ goals on the board every time out across their past 3 games in Serie A, and Sassuolo have conceded the most goals in the league.

Paulo Dybala in the Anytime Goalscorer market. Against Sassuolo in Serie A, he has found the net 4 times in his previous 5 appearances, but he is listed as injured, so confirm his availability before kickoff.

Make sure to get the best odds on your Same Game Parlay with Oddschecker's Exclusive Same Game Parlay Comparison Tool.

Same Game Parlay odds correct at time of publishing.

Roma vs Sassuolo Talking Points

The big storyline is Alberto Aquilani coming back to the Stadio Olimpico as an opposing manager for the first time, after more than 100 Serie A appearances for Roma as a player. Nostalgia won't fix his defense, though. After the Fiorentina loss, Aquilani said publicly that his side keep making avoidable errors and need more resilience, and Roma's wing play is the worst possible matchup for a back four that struggles to defend wide. Watch Wesley's flank against Simone Cinquegrano and Domenico Berardi, because that is where this game tilts.

Roma vs Sassuolo Predictions FAQs

When is the Roma vs Sassuolo Italian Serie A game?

The game kicks off at 2:45 PM ET / 11:45 AM PT on Saturday, November 7, 2026.

Where is Roma vs Sassuolo being played?

Roma vs Sassuolo is being played at the Stadio Olimpico.

What formations are expected for Roma vs Sassuolo?

Roma are expected to line up in a 3-4-2-1 formation, while Sassuolo are expected to use a 4-3-3 formation, based on the probable lineups.

Who is missing from Roma vs Sassuolo through injury?

Roma have Paulo Dybala, Manu Koné, Lorenzo Pellegrini and Mile Svilar listed as injured. Sassuolo have Fedde Leysen listed as injured, with Daniel Boloca and Ismaël Koné doubtful.

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