Kimsey/Ferguson/Hillier

South Florida travels to Greenville for a Friday night American Conference showdown against East Carolina, with both programs looking to remain competitive in a crowded conference championship race. Can Michael Van Buren and the Bulls overcome their recent offensive struggles against Mitch Griffis and a Pirates defense gaining momentum at home? Check out this South Florida vs. East Carolina prediction and best bet for Friday, November 6.

Nebraska travels to Champaign for a Friday night Big Ten showdown against Illinois, with both programs entering at 5-3 and looking to strengthen their bowl and conference positioning. Can Katin Houser and the surging Fighting Illini extend their three-game winning streak against Anthony Colandrea and a Cornhuskers defense that has been among the nation's best? Check out this Nebraska vs. Illinois prediction and best bet for Friday, November 6.

Virginia Tech travels to Dallas for a Friday night ACC showdown against SMU, with both programs entering at 6-2 and looking to strengthen their conference championship hopes. Can Kevin Jennings and the Mustangs overcome Ethan Grunkemeyer and a Hokies defense that ranks among the nation's leaders in sacks and tackles for loss? Check out this Virginia Tech vs. SMU prediction and best bet for Friday, November 6.

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