CFB Best Games to Watch Week 4: Previewing the Top College Football Matchups, Latest Odds
Texas-Tennessee headlines a loaded Week 4 slate, while Ole Miss-Florida, Oregon-USC and Texas A&M-LSU provide three more ranked matchups with major conference implications. Check out the best college football games to watch in Week 4, including start times, TV information and the latest odds.
Peter Alexis - September 23, 2026, 9:30 AM EDT
4 Minute ReadCollege Football Week 4 Headlined by Texas at Tennessee, Ole Miss at Florida, Six Total Ranked Matchups
Conference play takes over in Week 4, and the schedule is significantly deeper than last weekend. The SEC controls much of the spotlight with four ranked matchups, while Oregon and USC provide a fascinating West Coast Big Ten showdown in prime time.
No. 1 Texas gets the biggest stage with its first trip to Knoxville, but Ole Miss has another major test immediately after beating LSU and both LSU and Texas A&M need a response after disappointing losses. The night finishes with two explosive offenses meeting in Los Angeles.
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Best College Football Games to Watch in Week 4
No. 1 Texas vs. No. 14 Tennessee
- Date: Saturday, September 26
- Time: 12:00 PM ET
- TV: ABC
- Odds: Texas -3.5 | Total 56.5
Texas enters 3-0 after handling UTSA 30-6, with the comeback win over Ohio State still serving as the defining result of its early season. Tennessee is also undefeated after rolling past Kennesaw State 42-9, setting up Texas' first-ever trip to Knoxville with College GameDay in town.
The spread is surprisingly tight for the No. 1 team in the country. Texas opened around this range and remains only a field-goal-plus favorite, showing how much respect the market is giving Neyland Stadium and Tennessee's 3-0 start. Arch Manning against freshman Faizon Brandon also gives the game one of the weekend's most interesting quarterback storylines.
No. 4 Ole Miss vs. No. 21 Florida
- Date: Saturday, September 26
- Time: 3:30 PM ET
- TV: ABC
- Odds: Florida -3.5 | Total 60.5
Ole Miss climbed to No. 4 after beating LSU 32-24, with Trinidad Chambliss continuing his rapid rise into the Heisman conversation. Florida also enters unbeaten after surviving Auburn 44-39, and SEC Nation heads to Gainesville for a matchup between two of the conference's hottest teams.
The odds are arguably the most interesting part of the matchup. Despite Ole Miss holding the top-five ranking and the better signature win, Florida is a 3.5-point favorite at The Swamp. The 60.5 total is also among the highest numbers on the marquee slate, suggesting another game where both offenses should have opportunities.
No. 20 Oregon vs. No. 12 USC
- Date: Saturday, September 26
- Time: 7:30 PM ET
- TV: NBC
- Odds: Oregon -2.5 | Total 62.5
Oregon responded to its upset loss at Oklahoma State by annihilating Portland State 84-0, but USC provides a completely different test. The Trojans remain unbeaten after escaping Rutgers 42-35, and Jayden Maiava now gets another national stage against one of the Big Ten's most talented rosters.
The market still trusts Oregon enough to make the Ducks road favorites despite USC's higher ranking and home field. A 62.5 total is the largest among this week's featured games, and USC's defensive issues against Rutgers make this one of the clearest shootout candidates on Saturday.
No. 23 Texas A&M vs. No. 10 LSU
- Date: Saturday, September 26
- Time: 7:30 PM ET
- TV: ABC
- Odds: LSU -10 | Total 52.5
Both teams enter needing a response. Texas A&M was stunned 31-21 at home by Kentucky after beginning the year with two comfortable wins, while LSU fell 32-24 at Ole Miss in Lane Kiffin's emotional return to Oxford.
The double-digit spread is notable with two ranked 2-1 teams meeting, but LSU still commands enormous respect at Tiger Stadium. A&M went from a top-10 ranking to No. 23 after last week's loss, while LSU has an immediate opportunity to restore some of its preseason contender status.
Other Top College Football Games to Watch
Oklahoma vs. No. 2 Georgia
- Date: Saturday, September 26
- Time: 3:30 PM ET
- TV: ESPN
- Odds: Georgia -14 | Total 43.5
Oklahoma has fallen out of the rankings after losing to Michigan and then struggling through a 14-6 win over New Mexico. Georgia has had no such problems, improving to 3-0 with a 45-17 road win at Arkansas and looking every bit like a national-title contender.
Georgia laying two touchdowns tells the story of how differently these programs are currently viewed, while the low 43.5 total reflects Oklahoma's offensive problems and the strength of the Bulldogs defense. The Sooners' first SEC trip to Athens still gives the game plenty of historical appeal.
No. 17 Iowa vs. No. 18 Michigan
- Date: Saturday, September 26
- Time: 3:30 PM ET
- TV: CBS
- Odds: Michigan -4.5 | Total 37.5
This is the complete opposite of Oregon-USC. Iowa enters unbeaten after rushing for 422 yards against Northern Iowa, including three separate 100-yard rushers, while Michigan comes off a 52-17 win over UTEP. Both defenses rank among the strongest units either team has faced so far.
The 37.5 total is one of the lowest major-conference numbers of the weekend and fits the expected style perfectly. Michigan has also won four straight meetings against Iowa, while the Hawkeyes have not won in Ann Arbor since 2010.
No. 19 Missouri vs. No. 24 Mississippi State
- Date: Saturday, September 26
- Time: 7:45 PM ET
- TV: SEC Network
- Odds: Mississippi State -6 | Total 58.5
This quietly might be one of the best games on the entire board. Both teams are 3-0, with Missouri coming off a 27-17 win over Troy and Mississippi State entering the rankings after beating South Carolina 41-34 behind four touchdown passes from Kamario Taylor.
Mississippi State has also received substantial market respect, moving from roughly a field-goal favorite toward nearly a touchdown at home. With four straight meetings between these programs going over the total and an unbeaten season on the line for both sides, this has legitimate sleeper-game potential.
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