Los Angeles Rams vs. Arizona Cardinals Week 4 Complete Betting Preview and Odds

A blockbuster NFC West showdown is on the cards when the Los Angeles Rams and Arizona Cardinals collide in Week 4 at SoFi Stadium. Find out how the NFL odds stack up in this game preview, complete with betting tips and trends.
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Los Angeles Rams vs. Arizona Cardinals Week 4 Complete Betting Preview and Odds

Date: Sunday, October 3, 2021

Time: 4:05 PM ET

Location: SoFi Stadium, Inglewood

TV Network: FOX

Los Angeles Rams (3-0-0 SU, 2-1-0 ATS)

Arizona Cardinals (3-0-0 SU, 2-1-0 ATS)

Click Here For Rams vs. Cardinals Betting Odds

NFL Week 4 Matchup: Los Angeles Rams vs. Arizona Cardinals

The top spot in the NFC West is on the line when the Los Angeles Rams and Arizona Cardinals go head-to-head at SoFi Stadium this Sunday. If this matchup lives up to its billing, it should be a right cracker.

Sean McVay’s Rams are off to a flying start after going undefeated in September. The Rams won all three games, including last Sunday’s marquee showdown with the reigning Super Bowl champions, the Tampa Bay Buccaneers. Of course, things couldn’t be any better had McVay scripted it himself, validating his decision to bring in Matthew Stafford to replace Jared Goff, who’d fallen out of favor over the last few seasons.

Arizona Cardinals’ campaign is off to a stellar start, and if they keep this pace up, it may well be a banner season for third-year head coach Kliff Kingsbury and third-year quarterback Kyler Murray. On the back of Arizona’s 3-0 start, the Cardinals have seen their odds shrink in several markets while Murray has closed the gap on his peers in the MVP race.

Something’s got to give as these NFC West rivals fight for division supremacy. The Rams have the home advantage, earning the nod from bookmakers. However, the Cardinals are the quintessential dangerous floaters, and they’re getting a lot of action from bettors. So much so that the NFL has whittled down from an opening 6-points to 4.5-points. 

Los Angeles Rams Odds & Overview: In Stafford We Trust

The Rams enter a crucial stretch of the schedule with back-to-back NFC West contests against the Cardinals and Seahawks, respectively – the latter of which is a Thursday Night Football showdown. The premium on winning couldn’t be any more significant, nor could the occasion be any bigger. 

Beating the Cardinals at SoFi Stadium will be paramount to maintain a leg up in the division before heading to Seattle for another tough NFC West contest. The Seahawks were the Rams’ biggest rivals last season, and while the Seahawks won the division, the Rams eliminated the Seahawks from the playoffs in the Wildcard Round. 

The Rams are the better team and should win this game, but this is also a potential let-down spot. If the Rams look too far ahead, the Cardinals might capitalize. 

Arizona Cardinals Odds & Overview: Murry Mania

The Cardinals are out to prove they belong at the top of the NFC West this week, and if they pull off the feat, it will be something spectacular. However, the Cardinals are faced with the Rams and Niners in back-to-back weeks, which is a tough spot in the schedule. Not to mention, they’re set to play their second road game in as many weeks after making the trek to Florida in Week 3.

The Cardinals have had previous success against division rivals, but not nearly often enough and never at a pivotal juncture with a lot at stake. Since Kingsbury and Murray arrived in Arizona in 2018, the Cardinals have gone merely 3-9-0 SU and 4-6-2 ATS against NFC West opponents. 

Beating the Rams at SoFi Stadium on Sunday is a tough ask. The Cardinals were swept by the Rams last season, losing 38-28 in Week 13 and then 18-7 in Week 17. A lot has changed since then in both camps, providing new layers to this nuanced rivalry. 

The Cardinals stunned the Titans in Week 1, coming through as the 3-point road underdogs in the 38-13 upset. It was the only time this season the Cardinals were tipped as the underdogs. 

The following week, the Cardinals, closing as the 4-point home chalk, eked out a 34-33 win over the Vikings before crushing the Jaguars 31-19 last Sunday to cover as the 8-point road favorites.

Los Angeles Rams vs. Arizona Cardinals Odds

Cardinals+190+4.5 (-105)Over 55 (-105)
Rams-200-4.5 (110)Under 55 (-110)

Click Here For Rams vs. Cardinals Betting Odds

Los Angeles Rams vs. Arizona Cardinals Betting Preview

The Rams are coming off a gauntlet throwing win in Week 3, beating the Buccaneers 34-24 to move to the NFC frontline. The fact that the line has moved against the Rams is somewhat baffling. Wouldn’t the expectation be for the line to move in the other direction? 

No special injury announcements have been made to account for the drop from -6 to -4.5, leaving only the fact that the Rams are faced with a quick turnaround for a Thursday night showdown against the Seahawks as a possible explanation. The volume of betting coming down the wire is an additional contributing factor to the line moving in the direction of the Cardinals. As per consensus betting trends, 60% of the wagering tickets are on the Cardinals.


Nikki Adams is a freelance sports writer that’s honed in on the world of sports betting. She joined OddsChecker in 2021 after having covered a number of major American sports, including NFL and NCAAF, for several other publications in the industry. When she’s not looking for the best betting angles and writing engaging and insightful articles, she’s likely on a tennis court or binging on reality TV.

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