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MNF Week 6 Betting Preview, Odds, and Prediction: Buffalo Bills vs. Tennessee Titans by Nikki Adams

The Tennessee Titans are catching six points at home to the Buffalo Bills in Week 6 of the NFL. Do the bookmakers have it right? Join us as we preview this fascinating AFC showdown and serve-up betting tips.
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MNF Week 6 Betting Preview, Odds, and Prediction: Buffalo Bills vs. Tennessee Titans

The Tennessee Titans are catching six points at home to the Buffalo Bills in Week 6 of the NFL. Do the bookmakers have it right? Join us as we preview this fascinating AFC showdown and serve-up betting tips.

MNF Week 6 Betting Preview, Odds, and Prediction: Buffalo Bills vs. Tennessee Titans

Date: Monday, October 17, 2021

Time: 8:15 PM ET

Location: Nissan Stadium, Nashville, TN

TV Broadcast: ESPN

Buffalo Bills Record: 4-1-0 SU, 4-1-0 ATS

Tennessee Titans Record: 3-2-0 SU, 3-2-0 ATS

Buffalo Bills vs. Tennessee Titans Betting Odds

Buffalo Bills vs. Tennessee Titans Betting Preview

For the second straight week, the Buffalo Bills are on the road. After upsetting the Kansas City Chiefs at Arrowhead Stadium, the Bills travel to the Tennessee Titans, who are coming off a straightforward 37-19 win over the hapless Jacksonville Jaguars.

The Buffalo Bills vs. Tennessee Titans game is a matchup between current division leaders and AFC playoff hopefuls that are in good form right now. The Bills are riding roughshod over the AFC East behind a 4-1 record, while the Titans are in first place in the AFC South behind a 3-2 record.

Something’s gotta give when this pair collides at Nissan Stadium on Monday Night Football (MNF). Lookahead Week 6 NFL odds for this riveting MNF contest had Buffalo -2.5, but following Sunday’s NFL action, the markets reopened with Buffalo -3.5. That NFL line quickly shot up to Buffalo -6 with multiple sportsbooks as the public pounded the Bills following Sunday’s convincing victory at Arrowhead Stadium.

Super Bowl Odds

Buffalo Bills Odds & Overview

The Buffalo Bills are coming off an emphatic statement victory over the Kansas City Chiefs on Sunday Night Football. Any questions about the legitimacy of Buffalo’s Super Bowl credentials were answered – for the time being at least – as Josh Allen led the Bills to a surprising 38-20 rout of the Chiefs, which was an upset according to the NFL odds. The Bills closed as the 3.5-point road underdogs but came away with the outright upset.

The Bills went into the game on better form than the Chiefs, riding a three-game winning streak underscored by a scoring explosion. The Bills were the second-highest scoring team in the league -- albeit tied with the Chiefs on that score. And yet books had them at a disadvantage in the betting because doubt crept in, calling into question the quality of their winning run of form. They’d faced inferior teams and backup quarterbacks in all three games.

Well, so much for that. Allen and Company put paid on that notion quickly and absolutely. Allen was in sublime form and finished the night with 15 of 26 passing attempts for 315 yards and three touchdowns. He rushed for an additional score to cap his day with four touchdowns. Wide receiver Dawson Knox led the team with 117 yards and one touchdown on three receptions, while Emmanuel Sanders connected on three receptions for 54 yards and two touchdowns.

The Bills defense stepped up in a big way, too, quashing any notions about their validity as one of the stingiest D-units in the game. The Bills defense was holding teams down to a paltry 11 points per game before Sunday Night Football. Although they allowed the Chiefs to put up almost double, they frustrated Mahomes at every turn and pressured the Chiefs quarterback into two interceptions. They covered Tyreek Hill, holding the speedy receiver to merely 63 yards and zero touchdowns.

Tennessee Titans Odds & Overview

Tennessee bounced back into the win column Sunday with a routine 37-19 win over Jacksonville to improve to a 3-2 record. Mike Vrabel's side took full advantage of Urban Meyer’s hapless Jaguars and heaped more misery on the embittered head coach.

The Titans were entirely in control right from the off, exerting their dominance on the ground mainly. There was never any doubt about which team was the better team on the field.

Apparently, running back Derrick Henry loves to play the Jaguars. He showed that affinity for their division rival by torching the Jaguars' defense for 130 yards and three scores. The defense had a good turnout as well, sacking Trevor Lawrence twice and forcing one interception.

The one knockback is the inconsistent passing offense. Ryan Tannehill and the passing offense weren’t so sharp as the offensive line continues to struggle with pass protection. That’s going to be a real concern against Buffalo this Sunday.

Buffalo Bills vs. Tennessee Titans Odds

Buffalo Bills-5.5-240O 53.5 (-105)
Tennessee Titans+5.5+210U 53.5 (-105)

Buffalo Bills at Tennessee Titans Betting Odds | Football | OddsChecker

As mentioned above, the NFL line for this game has been hopping ever since bookmakers went to press. That has everything to do with the manner in which the Bills defeated the Chiefs on Sunday night, eliciting an almighty knee-jerk reaction in NFL betting circles. In fact, not only did the odds for this game climb significantly, but Buffalo Bills Super Bowl 56 odds improved dramatically too.

The Bills are now the second-best bet after Tampa Bay Buccaneers to lift the Lombardy Trophy. The Chiefs, on the other hand, dropped back to third overall in the NFL Futures market. Some sportsbooks have the Bills tipped as the top bet ahead of both Tampa Bay and Kansas City, which is quite the development after five weeks of NFL action.

Buffalo Bills vs. Tennessee Titans Betting Preview & Predictions

The Buffalo Bills are the NFL pick du jour. The vogue pick that the public is here for right now, and overwhelmingly so. Consensus betting reports reveal almost 90% of early betting has gone towards the Bills.

Could this be a letdown spot for the Bills? Perhaps. Following a big win, such as they delivered in Week 5, it’s not unusual to see teams come back down to earth with a bit of a thud. Granted, the Bills haven’t given any indication that such a wobble is imminent, but that doesn’t mean it cannot happen. The Titans beat the Bills 42-16 in their last meeting in 2020. Henry had a conservative day by his lofty standards, ratcheting merely 57 yards and two scores. Tannehill had a monster day, though, passing for 195 yards and three touchdowns while rushing for his fourth score.

In any event, if the betting continues to go in Buffalo’s direction, this NFL line could climb further. The Titans +6 at home are a tempting bet for NFL picks as it is, but if you can get the Titans at a higher number, then that would be even better.


Nikki Adams is a freelance sports writer that’s honed in on the world of sports betting. She joined OddsChecker in 2021 after having covered a number of major American sports, including NFL and NCAAF, for several other publications in the industry. When she’s not looking for the best betting angles and writing engaging and insightful articles, she’s likely on a tennis court or binging on reality TV.


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