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Los Angeles Rams vs. Buffalo Bills Betting Preview, Odds, and Overview

The NFL regular season opener is set for Thursday in Los Angeles. The Buffalo Bills are the betting favorite to win Super Bowl LVII and they will take on the defending Super Bowl champion Los Angeles Rams.
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Los Angeles Rams vs. Buffalo Bills Betting Preview, Odds, and Overview

The NFL will reward fans with an exciting opening matchup to kick off the 2022 season. Matthew Stafford and the defending Super Bowl champion Los Angeles Rams will host Josh Allen and the Buffalo Bills on Thursday night in SoFi stadium.

Buffalo enters Week 1 as the betting favorite to win Super Bowl LVII. This places a lot of pressure on the Bills to pick up right where they left off during an overtime shootout loss against Patrick Mahomes and the Kansas City Chiefs in the AFC Divisional Round. Buffalo rejuvenated its roster, notably signing former Rams defensive end Von Miller to the largest contract in free agency.

Super Bowl "hangover" is a popular expression. Yet, not all teams who win the Super Bowl start the next season sluggishly. The Rams could get off to a quick start with the return of Aaron Donald, plus the additions of Allen Robinson and Bobby Wagner to bolster personnel on both sides of the football.

Buffalo is a road favorite against the defending champion but its secondary remains on the mend. It will be tested by Matthew Stafford's reloaded arsenal of receiving options in a hostile environment.


Date: Thursday, September 8

Time: 8:20 pm ET

Location: SoFi Stadium (Inglewood, CA)

Los Angeles Rams Record: 0-0

Buffalo Bills Record: 0-0


Neither team faced each other in 2021 but Josh Allen led the Bills to a 35-32 win early during the 2020 season. Numerous roster changes have been made by both teams, increasing the difficulty of how which offense will prevail.

Looking at Los Angeles, it becomes evident that they are motivated to win another Super Bowl. The signing of All-Pro linebacker Bobby Wagner from Seattle, landing an underrated wide receiving talent in Allen Robinson, or convincing perennial All-Pro defensive tackle Aaron Donald to return for his ninth season all signal Sean McVay's hunger for more championships.

Rams quarterback Matthew Stafford has been nursing an elbow injury during training camp but all reports appear to be good heading into Thursday night. Cam Akers is another focal point, as the third-year running back managed to return from a torn Achilles to join the Rams on their Super Bowl run. His lackluster showing will be an intriguing storyline to watch unfold against a stout Bills front seven.

Buffalo saw their role players develop into significant contributors in 2021, most notably, wide receiver Gabe Davis. Will Davis make the jump to superstardom during his third year in the league? Playing alongside Stefon Diggs and catching passes from a prolific quarterback signal yes.

The Rams may have the better defense to start the season but both units ranked top five in TFLs and interceptions. The Bills allowed the second-fewest points (289) and while the Rams were very good, they surrendered 342 points. Bobby Wagner, Leonard Floyd, Aaron Donald, and Jalen Ramsey could be the glue that holds the Rams' championship aspirations intact down the stretch.


The latest Los Angeles Rams vs. Buffalo Bills odds slightly favor the Buffalo Bills on the moneyline and the point spread.

Last season, Los Angeles went 10-11 against the spread during their Super Bowl run. In their 17 regular season games, the Rams put up an 8-9 record ATS, tied ninth-best in the NFL.

Meanwhile, the Bills were markedly better when it came to their regular season record ATS, finishing 9-6-2 to rank fourth-best in the league.

Right now, according to the latest Rams vs. Bills odds, Buffalo is -130 on the moneyline and favored by 2 points on the road. The Rams' moneyline odds hover at +110.

ResultOddsSpreadTotal Points
Bills-130-2O51.5 (-115)
Rams+110+2U51.5 (-110)


Oddsmakers expect Josh Allen to pull out a win against an improved Los Angeles defense, but what is the betting public expecting on Thursday night?

Roughly two-thirds of public bettors are backing Buffalo to defeat the defending Super Bowl champion on the road. 62 percent of all moneyline bets on this game are backing the Bills, while only 38 percent are investing in the Rams.

ResultPublic Betting
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Matt is an avid writer, editor, and researcher. He enjoys analyzing the game within the game which is fantasy sports and sports betting. Music is another constant in his daily life. Matt loves spending time with his wife and three pets. He likes to read, listen to podcasts, and is constantly motivated to create the most accurate and engaging content in the sports betting industry.


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