Top Anytime Touchdown Scorer Picks for Lions vs. Bills on Thursday Night Football - September 17th
The Detroit Lions visit the Buffalo Bills on Thursday Night Football for Buffalo’s first regular-season game at the new Highmark Stadium, with the total climbing to a massive 54.5 points. Can Josh Allen, Jared Goff and two loaded groups of playmakers turn one of the season’s highest totals into another primetime shootout? Check out these Lions vs. Bills 5 anytime touchdown scorer picks for Thursday, September 17.
Peter Alexis - September 17, 2026, 5:00 PM EDT
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Five touchdown picks is more aggressive than the usual three, but Lions-Bills presents the type of environment where expanding the card makes sense. Detroit scored 31 points in its opener, Buffalo scored 36, and the two offenses combined for 67 points before even getting to a matchup carrying a 54.5 total that has continued to rise.
There is recent history behind the shootout potential as well. Buffalo won the last meeting 48-42 in December 2024, with Jared Goff throwing five touchdown passes and Josh Allen accounting for four scores as the teams combined for 90 points. With another game script expected to generate repeated red-zone trips and explosive plays, there is enough touchdown equity to take chances on several strong plus-money prices instead of narrowing the card to only three names.
Lions vs. Bills Date, Time, and Where to Watch
- Date: Thursday, September 17th, 2026
- Time: 8:15 PM ET
- Location: Highmark Stadium, Buffalo, New York
- How to Watch: Prime Video
Lions vs. Bills Odds
- Spread: Detroit Lions +5.5, Buffalo Bills -5.5
- Total Points: Over 54.5, Under 54.5
- Moneyline: Detroit Lions +195, Buffalo Bills -238
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Lions vs. Bills Best Anytime Touchdown Scorer Picks
1. DJ Moore Anytime Touchdown Scorer (+165) Check out the best odds at DraftKings Sportsbook
Moore made an immediate impact in his Buffalo debut, catching five passes for 100 yards and a touchdown in the 36-31 win over Houston. His score came on a 43-yard connection with Allen, while another deep target drew a pass-interference penalty at the one-yard line that directly set up an Allen rushing touchdown. Those are exactly the types of high-leverage opportunities that make Moore attractive in an anytime market.
The recent scoring trend backs it up, with Moore reaching the end zone in six of his last 10 games. His 43.46% projected touchdown probability is comfortably ahead of the 37.74% implied probability at +165, producing 15.17% EV.
Detroit's secondary also gave up 410 passing yards and three passing touchdowns to New Orleans in Week 1, creating another encouraging matchup for Allen's new top outside weapon. Moore already showed in one game that Buffalo is willing to feature him vertically, and another high-total environment creates plenty of chances for that role to produce a second straight touchdown.
2. Amon-Ra St. Brown Anytime Touchdown Scorer (+115) Check out the best odds at DraftKings Sportsbook
St. Brown enters Thursday already in scoring form after catching 10 passes for 67 yards and two touchdowns against New Orleans. Both scores came from Goff, including the four-yard overtime touchdown that ultimately helped Detroit escape with a 31-30 victory.
This is also a matchup in which St. Brown has already produced one of the biggest games of his career. He caught 14 passes for 193 yards and a 66-yard touchdown against Buffalo in the 48-42 meeting two seasons ago, showing how effectively Detroit can funnel the passing game through him when forced into an aggressive scoring script.
The +115 price implies a 46.51% scoring probability, while the projection sits at 53.37% for 14.75% EV. St. Brown has scored in four of his last 10 games, but the more important context is his role. He scored 11 touchdowns last season, opened 2026 with two more and remains Goff's most trusted option when Detroit needs a completion in condensed areas.
3. Sam LaPorta Anytime Touchdown Scorer (+240) Check out the best odds at DraftKings Sportsbook
LaPorta did not score in Week 1, but he remained heavily involved with five catches for 48 yards. He was also productive the last time Detroit faced Buffalo, finishing with seven receptions for 111 yards in a game where the Lions were forced to throw constantly while chasing points.
That previous performance is particularly interesting for the touchdown market. LaPorta did everything except reach the end zone in that 48-42 shootout, and another game with repeated red-zone opportunities gives him a chance to turn similar involvement into six points this time.
The projection gives LaPorta a 33.57% touchdown probability against a 29.41% implied probability at +240, creating 14.14% EV. He has scored in three of his last 10 games, so this is less about chasing a hot streak and more about getting better than 2-to-1 on one of the primary receiving options in an offense carrying one of the largest implied scoring expectations of the week.
4. Jameson Williams Anytime Touchdown Scorer (+220) Check out the best odds at DraftKings Sportsbook
Williams was quiet by his explosive standards in Week 1, finishing with four catches for 45 yards, but his role remains one of the most dangerous on the Detroit offense. His speed gives him the ability to score from outside the red zone, which is particularly valuable in a matchup where Buffalo may force Detroit to keep attacking rather than simply leaning on the running game.
He has already scored against this defense as well. Williams caught a three-yard touchdown with 12 seconds remaining in the 48-42 meeting in 2024, giving him a direct history of finding the end zone in this matchup.
Williams has scored in four of his last 10 games, while his 35.47% projected touchdown probability clears the 31.25% implied rate attached to +220 for 13.5% EV. St. Brown provides the high-volume route to a touchdown, while Williams offers the opposite profile. One deep connection, busted coverage or schemed shot can cash the bet immediately.
5. Dalton Kincaid Anytime Touchdown Scorer (+190) Check out the best odds at DraftKings Sportsbook
Kincaid may be the most interesting Buffalo option outside of Moore after opening the season with five catches for a career-high 130 yards. He averaged 26 yards per reception against Houston, including gains of 38 and 35 yards that helped set up Buffalo touchdowns.
The matchup gives his touchdown case another boost. Detroit allowed both Juwan Johnson and Noah Fant to catch touchdowns in Week 1, with the Saints repeatedly finding success through the middle and eventually throwing for 410 yards. Kincaid already caught four passes for 53 yards against Detroit in the 2024 shootout, and his role has expanded considerably since then.
Kincaid has scored in four of his last 10 games, while the projection places his touchdown probability at 38.28% compared to a 34.48% implied mark at +190, creating 11.01% EV. After a 130-yard opener without a touchdown, the volume and matchup both point toward another prominent role, and this time one of those big Kincaid receptions has a strong chance to finish in the end zone.
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