The Arizona Cardinals begin the Mike LaFleur era against a Los Angeles Chargers team coming off consecutive 11-win seasons. Jacoby Brissett, Trey McBride and Marvin Harrison Jr. give Arizona enough proven offensive pieces to test a large spread, while Justin Herbert debuts in Mike McDaniel's new offense. Check out this Cardinals vs. Chargers prediction and best bet for Sunday, September 13.

Read our San Diego FC vs Philadelphia Union prediction with latest odds, lineups, top betting picks, and Same Game Parlay insights for Sunday's MLS game.

The Cleveland Browns and Jacksonville Jaguars open the season with very different expectations after Jacksonville won 13 games and Cleveland finished near the bottom of the AFC. Deshaun Watson returns after a long absence for a Browns offense featuring an entirely rebuilt offensive line, while Trevor Lawrence leads the defending AFC South champions. Check out this Browns vs. Jaguars prediction and best bet for Sunday, September 13.

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