The Swiss is now odds-on in places to win a record ninth title at SW19.
In the biggest shock of the tournament so far, 3rd seed Marin Cilic crashed out of Wimbledon to Guido Pella – who has never won a match at The All England Lawn Tennis Club - in five sets having been two sets up overnight.
Cilic went into the match as 6/1 third favourite for the tournament. The Croatian would have been on course to meet favourite Roger Federer in the semi-final.
This now leaves Federer somewhat of a ‘free-run’ at the Wimbledon final – the four behind Federer in the market are in the other half of the draw – and bookies have reacted accordingly.
The 36-year-old reigning Champion is now as short as 5/6 to retain his title after being as big as 13/8 this morning, with even money the best price currently on offer with a few firms.
Milos Raonic was in the same quarter as Cilic, so the 2016 finalist has also seen his odds come in from 28/1 this morning to as short as 10/1 with one bookmaker.
Novak Djokovic remains the second favourite at 11/2 whilst French Open champion Rafael Nadal is still available to back at 13/2.
Oddschecker spokesperson, George Elek: 'With Federer, Djokovic and Nadal at the top of the Wimbledon Mens market, the competition is just lacking Andy Murray to stop it looking a decade old. 36-year old Federer remains in imperious form, and is the rightful favourite to win yet another SW19 crown.