There could be value in backing the Dane, who may profit after Simona Halep's early exit.
Over the last seven days Caroline Wozniacki has picked up the most amount of punters’ attention through Oddschecker, accounting for 14.6% bets.
With Halep suffering a shock loss on day one of the US Open, the Dane’s proportion has only increased with 19% over the last 24 hours.
Bettors have been keen to take the 25/1 top price on Wozniacki, who it must be pointed out, won the Australian Open at the start of the year, despite her injury problems.
The 29-year-old was forced to withdraw from the Citi Open in Washington, lost in the second round of the Montreal Open and was forced to retire after losing the first set against Kiki Bertens in Cincinatti.
Wozniacki is in the bottom half of the draw, which looks to be the more favourable, though she would have to face Wimbledon winner, Angelique Kerber in the Semi Finals.
Her record this year and grand slam pedigree suggests that if Wozniacki is anywhere near 100% fit, she could make a mockery of that pre-tournament price.
Oddschecker spokesperson George Elek said: “It’s very rare for the second seed in a grand slam tournament to be as high as 25/1 and that is attracting a lot of interest in the market.
“Just how serious an injury she has is very difficult to know but that price will quickly disappear if she dispatches of Sam Stosur tonight.”