19:30 Wednesday

Liverpool vs Luton – Liverpool

Luton Town face a daunting task as they head to Anfield to challenge Premier League leaders Liverpool this evening.

Despite securing a convincing 4-1 victory against Brentford last Saturday to strengthen their position at the league's summit, Liverpool encountered setbacks during the match. 

Three of Klopp's players had to be substituted due to injuries - Curtis Jones, Diogo Jota and Darwin Nunez. Liverpool hold a four-point lead over third-placed City, albeit having played one more game. 

They are separated from second-placed Arsenal by just two points. Liverpool have maintained an impeccable record at Anfield, remaining unbeaten in all competitions on home turf.

Meanwhile, Luton Town's early struggles against Manchester United cost them a potential positive outcome. Rasmus Hojlund netted twice within the first seven minutes for the Red Devils, although the Hatters rallied admirably afterwards. 

Despite showing improved form away from home recently, Luton Town are unlikely to overcome Liverpool at Anfield. Their defensive vulnerabilities persist, whereas Liverpool - despite injury concerns = boast sufficient quality players to secure a clean sheet and claim victory on Wednesday.

20:00 Wednesday

FC Porto vs Arsenal – Arsenal & BTTS

Currently occupying the third spot in the Liga Portugal standings, FC Porto haven’t hit top form this season and will be looking to kick start the season with this last 16 match with Arsenal 

Following their dominant 5-0 win against Burnley, Arsenal will approach this upcoming fixture with confidence. The Gunners have shown remarkable form over the past month, with 21 goals scored in their last five matches.

20:00 Wednesday

Napoli vs Barcelona – Barcelona 

Barcelona currently holds the third spot in the La Liga standings but have struggled to meet expectations this season and will be looking to go all the way in the Champions League. 

Napoli sit in ninth place in the Serie A table and have underperformed this season. Following a 1-1 draw against Genoa over the weekend, they must improve their performance against Xavi's side.

Barcelona have been inconsistent this season, particularly in matches where they were expected to dominate. They've faced several disappointments in the UEFA Champions League in recent years and are eager to rectify their form this season.

While Napoli can pose a threat on their best days, they have various issues to address in the near future. Barcelona hold the edge in quality and are poised to clinch victory in this encounter.