England face Spain in a huge Nations League opener at Wembley, with the World Cup winners returning to action against an England side looking to make a strong start under Thomas Tuchel.

The fixture is another meeting between two of Europe's biggest international sides, with Spain arriving as the reigning world champions after their World Cup triumph in July. England, meanwhile, will be looking to respond following their semi-final exit and begin a new Nations League campaign on home soil.

Who is the Betting Favourite in England vs Spain?

According to latest odds on Oddschecker, Spain are the betting favourites to beat England in the UEFA Nations League, priced around 5/4 for the away win. England are priced at 2/1, while the draw is near 3/1.

England vs Spain Best Bet

Best Bet: Lamine Yamal - Over 1.5 Shots On Target
Odds: 11/8 (Coral)
Stake: 1pt

Lamine Yamal has quickly established himself as one of Spain's most dangerous attacking players, and his willingness to shoot makes the 1.5 shots-on-target line particularly interesting against England.

Yamal has recorded 2, 0, 2, 2, 4 and 0 shots on target across his World Cup starts, clearing this line in four of those six matches. His domestic numbers have been even more consistent this season, with his last eight league matches producing 1, 2, 2, 2, 4, 2, 3 and 0 shots on target.

That means Yamal has registered at least two shots on target in six of his last eight domestic appearances, including four or more on target in two matches. His ability to cut inside from the right and attack defenders before getting a shot away gives him plenty of routes towards the target.

At 11/8, Yamal to register two or more shots on target is our best bet for England vs Spain.

Lamine Yamal Over 1.5
England v Spain [Player Shots On Target]
7/5

England vs Spain Bet Builder Tip

England vs Spain Bet Builder:

  • Harry Kane - Over 1.5 Shots On Target
  • Lamine Yamal - Over 1.5 Shots On Target
  • Rodri - Over 2.5 Tackles
  • Elliot Anderson - Over 2.5 Tackles

Best odds of 9/1 at SpreadEx while publishing.

Harry Kane Over 1.5 Shots On Target

Harry Kane's record for England provides plenty of encouragement for this line, with the striker recording 0, 2, 1, 3, 2, 1, 3 and 1 shots on target across his last eight starts for the Three Lions.

That means Kane has cleared 1.5 shots on target in three of his last four England starts, while his current club form has also produced plenty of shooting volume. His last five matches for Bayern Munich have seen him record 3, 1, 2, 2 and 0 shots on target.

England will need Kane heavily involved if they are to trouble Spain, and his ability to drop into deeper areas before arriving in the box should give him opportunities to test the Spanish defence.

Lamine Yamal Over 1.5 Shots On Target

Yamal is the obvious second attacking leg, with the Barcelona winger producing an impressive volume of shots on target for both club and country.

His World Cup starts have returned 2, 0, 2, 2, 4 and 0 shots on target, while his numbers this season read 1, 2, 2, 2, 4, 2, 3 and 0. He has therefore reached two or more shots on target in six of his last eight domestic matches.

Yamal is also in the form of his life in La Liga, wreaking havoc alongside Raphinha, and Spain will look to him to provide the individual quality capable of unlocking England's defence.

Rodri Over 2.5 Tackles

Rodri could have a huge role to play in the middle of the pitch against an England side packed with attacking talent.

The Spanish midfielder recorded 4, 4, 1, 4, 5 and 5 tackles across his last six World Cup starts, clearing the 2.5 line in five of those six matches. His domestic numbers this season have been 5, 1, 3, 2 and 1, showing that he is gradually getting back into the rhythm after arriving late from the World Cup and making the move from Manchester City.

Against England's midfield runners, Rodri should be required to make plenty of defensive interventions, making three or more tackles an appealing leg for the bet builder.

Elliot Anderson Over 2.5 Tackles

Elliot Anderson could be another busy figure in the centre of the pitch, particularly with England likely to face plenty of possession from Spain.

The midfielder's last eight starts for England have produced tackle numbers of 4, 2, 5, 2, 2, 3, 2 and 3, meaning he has cleared 2.5 tackles in three of his last four starts.

His club form also points towards plenty of defensive involvement. Anderson's last five matches this season have returned 2, 3, 1, 5 and 2 tackles, giving him an average of 2.82 tackles per 90 minutes.

With Spain expected to dominate possession for spells, Anderson's role in disrupting their midfield circulation could give him plenty of opportunities to reach three tackles.

England vs Spain Player Bet

Best Bet: Harry Kane - To Score or Assist
Best Odds: 21/20 (QuinnBet)
Stake: 1pt

Kane remains England's focal point in attack and arrives at Wembley after an outstanding campaign with Bayern Munich. The striker's ability to contribute either as a goalscorer or creator makes the score-or-assist market particularly appealing in a game where England should have to find ways through a strong Spain defence.

His recent England numbers also show that he remains heavily involved in front of goal, while his shot-on-target record gives us another indication of how frequently he gets himself into positions to influence matches.

With Kane capable of finishing chances himself or dropping deep to bring England's attacking players into the game, backing him to score or assist provides two routes to a winning bet.

Harry Kane
England v Spain [To Score Or Assist]
5/4