While the clash between Aston Villa and Sheffield United is a big game in it's own right at both ends of the table, there's little doubt Premier League fans will be eagerly anticipating the late kick-off when action returns on Wednesday.

Manchester City host Arsenal in the second game of the night, with Mikel Arteta - formerly the assistant to Pep Guardiola - making his first return to the Etihad Stadium. It's safe to say both teams will be keen to make their comeback in strong fashion having seen a number of players recover from injuries during a three-month absence from football.

Ahead of the marquee match in Manchester, WhoScored.com have researched another Request A Bet that has been priced up at a mouth-watering 66/1 by Sky Bet this week.

Pierre-Emerick Aubameyang to score

While there is no question that the home team are the strong favourites for good reason, Arsenal were one of the form sides prior to lockdown, inspired by their talismanic captain. Indeed, Aubameyang's form in front of goal has thrust him back into contention for the Golden Boot once more, with nine of his 17 league goals this season coming from 12 appearances away from home. No Premier League player has scored more goals on the road all season, while the Gunners have found the net in all but one of 15 matches under Arteta.

Kevin De Bruyne to score from outside the area

The star man in the reverse fixture between these sides back in December, and arguably to top Premier League performer all season, De Bruyne tends to enjoy facing Arsenal. His brace at the Emirates earlier in the campaign took his tally to four goals against the Gunners, which is more than he has scored against any other English club. Two of said strikes came from outside the box, and more than half of his goals in the league over the last four seasons have come from distance (13 of 24).

Manchester City to win by 2+ goals

Though there is no denying that Arsenal have made progress under their rookie boss, with the likes of Aymeric Laporte and Leroy Sane now back available, Pep Guardiola has a fully fit squad to choose from. He's yet to face his former right hand man but the Spaniard has had the Gunners' number in recent years, with City winning each of the last six meetings between the sides by at least two clear goals.

Granit Xhaka to be carded

It may seem like an obvious lean when looking into the cards market, but Xhaka's record in this fixture is essentially unavoidable. Renowned for his his lack of timing in the tackle - with seven yellow cards this season putting him on course for double figures for the third season running - the midfielder tends to fall foul of the referee in big matches in particular. The Swiss international has been booked in four of his last six appearances against Manchester City, having missed the previous two meetings between the teams.