France v Italy - 14:25 BBC1
In his confirmed final campaign, Azzurri coach Jacques Brunel is also giving youth its chance and surprisingly in some key areas of the pitch for early control away from home - the front-row, at fly-half and at full-back.
The best bets are Maxime Medard to score a try at 15-8 and Gael Fickou to score a try at 2-1. Noves coached both men at Toulouse and is trusting them to show their skills. Plenty of attention will be focused on stopping debutant Sevens specialist Virimi Vakatawa on the left wing but Medard runs sharp lines from full-back at the speed of a winger.
Medard has 11 tries in 41 caps and has five tries in 14 club outings this season. Outside centre Fickou is flying for Toulouse at the moment with eight tries in 11 games since returning from the World Cup where he scored against Romania and was influential in a 32-10 win over Italy.
France beat Italy 29-0 in Rome last year and have beaten them 30-10, 30-12 and 46-20 in their last three Six Nations clashes in Paris.
Scotland v England - 16:50 BBC1
The home support should be solid and sustained after Scotland got so close to a World Cup semi-final and not just anti-English. And gruff Kiwi coach Vern Cotter will not have allowed complacency in the build-up or allowed his squad to forget that they lost all five Six Nations matches last year. A specialist contact and breakdown coach has been brought in to try and eliminate tackle and turnover errors.
There are two changes to the Scotland starting side that were edged out by Australia in the autumn - John Barclay in at openside flanker for Blair Cowan and Matt Scott at inside centre for the injured Peter Horne - but they are not negatives. Barclay has been superb for Scarlets after the disappointment of missing out on World Cup squad selection and injury issues have stopped Edinburgh man Scott from making the 12 shirt his own.
New England coach Eddie Jones has certainly paid respect to Scotland with his team selection. There are no starting debutants for all the early talk as the first foreign England head coach of a new dawn after the disappointment of the World Cup pool stage exit. And the George Ford-Owen Farrell combination at fly-half and inside centre, while no shock, suggests that England will only want to play expansive rugby deep in Scotland territory and with control of the ball at the set-piece. New captain Dylan Hartley, returning after his World Cup-omission following a ban, promises that at hooker with an excellent lineout throw and power at the scrum but he like many of those forwards who have retained their places are prone to giving away soft penalties. Wales punished them at the World Cup primarily through the boot of Dan Biggar and Scotland have a dead-eye kicker of their own in skipper Greig Laidlaw.
Scotland have stiffened up at scrum-time with WP Nel at tighthead and they have battlers throughout the lineout and breakdown, none more so than bedded-in Kiwi import John Hardie.
England do still look the superior side but they are just unlikely to surge clear like they have in the last three Calcutta Cups and on two of those occasions, Ladbrokes' 38.5 total points mark has not been reached. Indeed England's 2013 38-18 Twickenham triumph is the only last eight meetings that the line has been breached, have a bet that it won't be this time too.