Heisman Trophy Odds: Favorites Square Off with Dante Moore, Fernando Mendoza in Indiana vs. Oregon Clash
The 2025 Heisman Race has a couple star quarterbacks at the top, all with a top-15 battle on Saturday to prove their worth. Dante Moore and Fernando Mendoza will square off in a top-10 Big Ten clash on Saturday afternoon when Oregon hosts Indiana, which could very well determine the Heisman frontrunner. Peter Alexis breaks down the latest Heisman Trophy odds ahead of Week 7.
Peter Alexis - October 11, 2025, 11:45 AM EDT
5 Minute ReadHeisman Trophy Odds: Can Dante Moore Remain Favorite Against Fernando Mendoza, Hoosiers in Week 7
The Heisman Trophy race is heating up as Oregon quarterback Dante Moore has taken over as the frontrunner following Week 5's thrilling double-overtime win over Penn State. Moore was spectacular once again, flashing his dual-threat ability and poise in key moments as the Ducks stayed undefeated. Now sitting at +550 odds, the sophomore is leading one of the most explosive offenses in the nation and will look to strengthen his case on the biggest stage of the season so far.
His next test comes against another Heisman contender in Indiana’s Fernando Mendoza, who currently sits at +1400. Mendoza was an early favorite a few weeks ago after several impressive performances but has slipped slightly following a quiet outing in a win over Iowa. Despite that, he remains a dangerous dual-threat presence who can quickly reclaim national attention with a statement game in Eugene.
This showdown between Oregon and Indiana has massive implications for both the playoff picture and the Heisman race. Moore will try to build separation as the favorite, while Mendoza has the chance to vault himself back into the conversation with a road upset. Oregon enters as a 7.5-point favorite at Autzen Stadium, and the outcome could go a long way in determining who controls the Heisman spotlight heading into midseason.
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Heisman Trophy Odds
Heisman Trophy Odds Breakdown
Dante Moore (+550) Click here to bet on Dante Moore at FanDuel
Oregon’s Dante Moore has surged to the top of the Heisman odds after his standout performance in the double-overtime win over Penn State. The sophomore signal-caller continues to impress with his calm decision-making, accuracy, and ability to extend plays under pressure. If he delivers another big showing against No. 10 Indiana this weekend, Moore could further solidify his position as the frontrunner heading into the heart of Pac-12 play.
Carson Beck (+650) Click here to bet on Beck at FanDuel
Carson Beck has been the steady leader of undefeated No. 2 Miami, guiding the Hurricanes to an impressive 5-0 start that includes a road win over ranked Florida State. Miami is off this week, but Beck’s next opportunity to shine comes next Friday against Louisville in another marquee matchup. If he keeps stacking wins and producing efficiently, he’ll remain one of the top names in the Heisman race as the season’s second half approaches.
Ty Simpson (+850) Click here to bet on Simpson at FanDuel
Alabama’s Ty Simpson has quietly climbed into the top tier of contenders after leading the Crimson Tide to several strong wins. He’ll get one of his biggest tests yet on the road against Missouri in a top-15 showdown that could define both his Heisman chances and Alabama’s playoff hopes. Simpson’s ability to make clutch throws and keep the Tide’s offense balanced will be crucial in this matchup. A dominant performance in Columbia could propel him right alongside or even ahead of Moore.
Fernando Mendoza (+1400) Click here to bet on Mendoza at FanDuel
Indiana’s Fernando Mendoza remains firmly in the Heisman conversation despite slipping a bit in recent weeks. Once the odds leader, Mendoza’s production dipped in the Hoosiers’ win over Iowa, but he has a massive chance to rebound on the national stage this weekend at Oregon. A road upset over the Ducks would not only put Indiana in serious playoff contention but could vault Mendoza right back into the top tier of Heisman candidates. With the lights bright at Autzen Stadium, this could be his defining moment.
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