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Stanford vs. Arizona State Odds: Cardinal Open as Big Underdogs to Sun Devils

Can Stanford defy the NCAA football odds as it travels to No. 22 Arizona State and serve up back-to-back upsets over ranked opposition? Find out as we preview this marquee Pac-12 showdown
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Stanford vs. Arizona State Odds: Cardinal Open as Big Underdogs to Sun Devils

Date: Friday, October 8, 2021

Time: 10:30 PM ET

Location: Sun Devil Stadium, Tempe, AZ

TV Broadcast: ESPN

Stanford Cardinal Record: 3-2, 2-1 Pac-12

Arizona State Sun Devils Record: 4-1, 2-0 Pac-12

Stanford vs. Arizona State odds

NCAA Football Week 6 Matchup: Stanford vs. Arizona State

Stanford looks to back up its big upset over No.3 Oregon Ducks this Saturday when it squares up to a second-straight ranked opponent, No.22 Arizona State, in as many weeks.

No.22 Arizona State was reinstated inside the Top 25 of the Associated Press college football poll this week after serving up an upset over UCLA in Pasadena Saturday night. Now, they’ll be keen to keep the momentum going at the expense of Pac-12 foes, Stanford, when the pair collides at Sun Devil Stadium.

Books opened Stanford vs. Arizona State odds with the Cardinal catching 9.5-points on the board, but the line jumped up to 10 points Sunday. The game total opened at 52 points.

Stanford Cardinal Odds & Overview

Stanford Cardinal delivered arguably the biggest upsets of the weekend, defeating one of the top College Football Playoff contenders with a 31-24 come-from-behind victory in overtime against the No.3 Oregon Ducks. Stanford closed as the 8.5-point home underdogs, and came through for their backers in the stunning victory.

Cardinal sophomore quarterback Tanner McKee rallied his side late in the fourth quarter to knot the game at 24-24. He reeled off 11 plays for 87 yards on the final drive, capping it off with a two-yard toss to Elijah Higgins for the touchdown. In overtime, McKee, once again, rose to the occasion by converting a third-and-long pass, connecting with John Humphreys for the game-winning touchdown.

Head coach David Shaw was elated by his side’s performance, the grit and determination displayed in the fight for the victory. In particular, he was most effusive about McKee’s clutch play towards the end. “Can't say enough about our young quarterback,” gushed Shaw in his post-game presser. Adding that McKee “did not play perfectly, did not play his best game, but doggone it, he is special. He is special.”

Arizona State Odds & Overview

Arizona State snapped a two-game losing streak to UCLA on Saturday, clinching the impressive 42-23 win as the 3-point closing underdogs on the road. On the heels of the victory, Arizona State jumped back inside the AP Top 25 at No.22 and climbed to the top spot in Pac-12.

Herm Edwards' side started the season as the No.25 ranked team, but a loss to BYU a couple of weeks ago dropped them outside the frame. So, that UCLA win was validating, getting Arizona State back into the conversation.

The Sun Devils beat the Bruins resoundingly, totting up 458 yards of offense and averaging nine yards per play. Arizona State's defense was astounding, shutting down UCLA in the second half, while the offense put in a strong performance, led by junior quarterback Jayden Daniels.

The Sun Devils led 24-23 at the half and scored 18 unanswered points in the second half. Daniels threw for 286 yards on 13-of-18 passing for two touchdowns, twice connecting with wide receiver Ricky Pearsall in the second quarter for the score. The junior signal-caller added another 45 yards on the ground.

Stanford Cardinal vs. Arizona State Odds

TeamPoint SpreadMoneylineOver/Under
Stanford+11+360Over 52
Arizona State-11-410Under 52

Stanford vs. Arizona State odds

Stanford and Arizona State face a short week as they collide in primetime Friday night football. Arizona State is on the rise in national estimation, and books have taken stock, opening the Sun Devils at -9.5 Sunday.

Since then, the line has moved to Arizona State -10 with most top-rated market operators. However, some shops are already showing Arizona State -10 with higher juice (-120), signaling the likelihood of further movement across the board as more betting comes down the wire during the week.

Arizona State's offense is clicking, and in the last two games, the Sun Devils have put up a combined total of 77 points. Overall, Herm Edward's side is averaging 34.4 points scored per game this season. By contrast, Stanford is averaging 29 points scored per game this season.

Stanford Cardinal vs. Arizona State Betting Preview

Stanford is 3-2 overall and 2-1 in Pac-12 action with an average winning margin of 2.2 points. In ATS betting, the Cardinal are 3-2-0 ATS with a +6.2-point differential versus the spread. The over has cashed in two of their five games this season – against USC and Vanderbilt.

Arizona State is 4-1 overall and 2-0 in Pac-12 action with an average winning margin of 17 points. In ATS betting, the Sun Devils are 2-3-0 ATS with a -1.7-point differential versus the spread. The over has cashed in two of their five games this season – against Colorado and UCLA.

Early consensus betting reveals a slight lean towards Stanford in point spread betting markets, as 60% of early bets grabbed the Cardinal plus the points. Whereas game total consensus betting trends show an overwhelming lean towards the over, signaling a shootout may be on the cards.


Nikki Adams is a freelance sports writer that’s honed in on the world of sports betting. She joined OddsChecker in 2021 after having covered a number of major American sports, including NFL and NCAAF, for several other publications in the industry. When she’s not looking for the best betting angles and writing engaging and insightful articles, she’s likely on a tennis court or binging on reality TV.


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