Los Angeles Rams vs. Buffalo Bills Against the Spread, Betting Odds: Bills Get 57% Chance To Spoil Rams' Night

The Los Angeles Rams begin their title defense when they host the Buffalo Bills to kick off the 2022-23 NFL season. Let's take a closer look at the Rams vs. Bills.

Colby Faria - September 8, 2022, 10:08 AM EDT

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Los Angeles Rams vs. Buffalo Bills Against the Spread, Betting Odds: Bills Get 57% Chance To Spoil Rams' Night

The first game of the 2022-23 NFL season begins where the 2021-22 campaign ended as the reigning Super Bowl Champion, Los Angeles Rams host Josh Allen, and the Buffalo Bills kick off the season.

Let's take a closer look at the NFL's opening night matchup.

Los Angeles Rams vs. Buffalo Bills Start Time, How To Watch, and Odds

When: Thursday, September 8, 2022
Time: 8:20 p.m. EDT/5:20 p.m. PDT
Where: SoFi Stadium, Los Angeles
How To Watch: NBC, NBC Universo

Los Angeles Rams vs. Buffalo Bills Breakdown

The defending Super Bowl Champion, Los Angeles Rams hope to be the NFL's first back-to-back champions since the burgeoning dynasty in Foxboro, when the Patriots won back Super Bowls in 2004 and 2005, respectively. Sean McVay's squad is of course led by their trio of All-Pros in the form of corner, Jalen Ramsey, defensive lineman, Aaron Donald, and last season's Super Bowl MVP, wideout, Cooper Kupp. The most notable departure in LA was pass rusher, Von Miller, who left for Buffalo this off-season, however, the Rams added another former All-Pro to the mix as Bobby Wagner came over from Seattle in free agency.

Meanwhile, Sean McDermott and co. will look to spoil the party at SoFi Stadium, Thursday night. The Bills exited the playoffs in dramatic fashion, last season when their season ended in Kansas City during the divisional round. However, oddsmakers are backing Josh Allen and the Bills to take the next step as according to the odds, Buffalo will be hoisting the coveted Lombardi Trophy, come next February.

Los Angeles Rams vs. Buffalo Bills Odds

Team	Spread	Moneyline	Total
Buffalo Bills	-1.5	-135	O 52
Los Angeles Rams	+1.5	+110	U 52

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