Oddschecker+
Positive EV Bets
Odds format
United States
Canada
OH
United States
Canada
Minnesota Twins Pablo Lopez

Twins vs. Cardinals Prediction: Can Pablo Lopez, Twins Overpower Cardinals on Opening Day?

The Minnesota Twins will start on the road at Busch Stadium today against the St. Louis Cardinals. Can Pablo Lopez and the Twins pick up an away victory to start the season vs. Sonny Gray and the Cards? Next Level Bets thinks so, and explains why in his Twins vs. Cardinals prediction and best bet for MLB Opening Day.

Twins vs. Cardinals Prediction: Can Pablo Lopez, Twins Overpower Cardinals on Opening Day?

Opening Day is finally here! Baseball is back, and we have a solid matchup between two teams looking to start the season on the right foot. Let’s break it down and find the best bet for today’s game.

Get your first month of oddschecker+ right now for just $0.99. Don't miss out on this March Madness deal!

Twins vs. Cardinals Odds

  • Spread: Twins -1 (+120), Cardinals +1 (-150)
  • Moneyline: Twins (-115), Cardinals (+100)
  • Total: Over 7.5 (+100), Under 7.5 (-113)

Minnesota Twins vs. St. Louis Cardinals Date, Time, and Where to Watch

  • Date: Thursday, March 27, 2025
  • Time: 4:15 PM ET
  • How to Watch: Fubo, Fox Sports Midwest

Click here for latest Twins vs. Cardinals Odds

Minnesota Twins vs. St. Louis Cardinals Prediction

The Twins come into this season with high expectations, boasting a strong bullpen, solid starting rotation, and a lineup that can do damage. They’ll face Sonny Gray, who had a rough spring training and now has to go up against one of the better lineups in the league right out of the gate.

On the mound for Minnesota will be Pablo López, a reliable arm who may not be in his prime anymore but still put together a decent showing in spring training. While he isn’t a dominant ace, he should be steady enough to give the Twins a strong chance, especially with their bullpen likely playing a key role late in the game.

With the edge in pitching depth and an offense that can take advantage of Gray’s struggles, the Twins have the upper hand here. Expect them to start the season with a win.

Minnesota Twins vs. St. Louis Cardinals Pick

MLB ODDS

onboarding-background

Join the oddschecker Community

Bet with Intelligence

Sign-up for an oddschecker account to get expert picks, ai-driven betting tools and best odds across sportsbooks.