Diamondbacks vs. Yankees Prediction, Betting Pick, Latest MLB Odds for Wednesday, April 2nd

We've got a good series unfolding between the Arizona Diamondbacks and New York Yankees in the Bronx. There were five home runs, including a game-changing Grand Slam by Eugenio Suárez in the 8th inning to grab a 7-4 lead.

The Yankees will bring Carlos Rodon back on the mound on Wednesday in an effort to bounce-back from their first loss of the season. Rodon looked good on Opening Day, allowing one earned run and recording seven strikeouts in 5.1 innings pitched during a 4-2 win over the Brewers.

Arizona will trot out Zac Gallen against the Yankees' lethal Torpedo bats Wednesday night. Gallen gave up four earned runs on four hits in 4.0 innings pitched against the Cubs on Opening Day. This included a home run, four walks, and four strikeouts. The Diamondbacks went on to lose 10-6.

MLB handicapper Matt MacKay is here to share his best game pick to place between the Arizona Diamondbacks vs. New York Yankees on Wednesday night using the latest odds. Follow Matt's X account for more MLB betting insight and free picks during the 2025 MLB season.

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ARIZONA DIAMONDBACKS VS. NEW YORK YANKEES ODDS

• Spread: Diamondbacks +1 (-112), Yankees -1 (-109)
• Moneyline: Diamondbacks (+135), Yankees (-138)
• Total: Over 8 (-115), Under 8 (+100)

ARIZONA DIAMONDBACKS VS. NEW YORK YANKEES DATE, TIME, AND WHERE TO WATCH

• Date: Wednesday, April 2, 2025
• Time: 7:05 PM ET
• How to Watch: Prime Video

Click here for latest Diamondbacks vs. Yankees Odds

ARIZONA DIAMONDBACKS VS. NEW YORK YANKEES PREDICTION

Rodon versus Gallen offers an intriguing matchup to bet tonight. Rodon went 16-9 as a starter for the Yankees in 2024, finishing with a 3.96 ERA and 195 Ks. Gallen was equally as successful, going 14-6 with the Diamondbacks last season, recording a 3.65 ERA and 156 Ks.

These pitchers could go either way against lineups that have top-tier production and talent. New York erased an early deficit against Arizona on Tuesday night, hitting solo home runs in the 3rd and 4th innings to tie the game 2-2. Then, a throwing error by the Diamondbacks allowed the Yankees to get two more runs, creating a 4-2 lead until the 8th inning.

The Diamondbacks have been good on the road dating back to last season, going 5-1 SU. Most trends suggest that the run total will go over 8, which is why oddsmakers have over 8 total runs at -115 odds. This is a likely outcome, especially with Rodon and Gallen each giving up a home run in their lone starts.

Instead of a total, I'm going to bet a side in the second game of this series. Arizona has only held a lead after the first 5 innings once in five games played. The Diamondbacks tend to get their bats going against opposing bullpens, while the Yankees are 4-0 in the First 5 Innings market in 2025.

Both lineups can and will do damage on Wednesday night in Yankee Stadium's shallow ballpark. New York's red-hot right now, while the Diamondbacks are adjusting to their new-look lineup, no longer with power hitter Christian Walker batting clean-up.

Arizona's scored 12 total runs in the first 5 innings through five games played. In comparison, New York's scored 27 total runs in the first 5 innings through only four games. 16 of these runs came during their 20-9 rout of Milwaukee on March 29th.

It's pretty obvious where I'm going with this pick. Let's bet a unit on the New York Yankees First 5 Innings Moneyline at -130 odds against the Arizona Diamondbacks at home on Wednesday night.

ARIZONA DIAMONDBACKS VS. NEW YORK YANKEES PICK

• Pick: New York Yankees First 5 Innings Moneyline (-130) Click here to see which sportsbook has the best price on Diamondbacks vs. Yankees odds

MLB ODDS

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