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Padres vs. Astros Prediction: Can Dylan Cease, Padres Avoid Sweep in Houston on Sunday Night?

The San Diego Padres will attempt to avoid the sweep on Sunday Night Baseball and get back to their winning ways. Can Dylan Cease and the Padres pick up a crucial road win over the Houston Astros tonight? Next Level Bets breaks down this Padres vs. Astros prediction for Sunday, April 20th.

Padres Dylan Cease

Next Level Bets

| 4 min

Padres vs. Astros Prediction: Can Dylan Cease, Padres Avoid Sweep in Houston on Sunday Night?

Today we have a very good game between two solid teams with elite pitchers on the mound — Dylan Cease for the Padres and Framber Valdez for the Astros. Both teams have playoff-level talent and tonight should be a competitive battle from start to finish. Let’s find the best bet for this marquee matchup!

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Padres vs. Astros Odds

  • Moneyline: Padres (+108), Astros (-125)
  • Runline: Padres +1.5 (-200), Astros (-126)
  • Total: Over 7.5 (-104), Under 7.5 (-118)

Padres vs. Astros Date, Time, and Where to Watch

  • Date: Sunday, April 20, 2025
  • Time: 7:10 PM ET
  • Where to Watch: ESPN

Click here to see complete Padres vs. Astros Odds

Padres vs. Astros Prediction

We’ve got a heavyweight pitching battle tonight with Dylan Cease going up against Framber Valdez, and while both are capable of dominating, this sets up as a great spot for the Padres to come out on top.

Cease has been sharp to start the season, flashing his elite strikeout stuff and showing improved command. He’s been tough on lefties — which is key when facing a Houston lineup that leans on bats like Alvarez. On the other side, Valdez has looked great too but this padres line up has been ho

This feels like a low-scoring, tight game where the edge goes to the bullpen and the better overall form — and right now, that leans San Diego. With Cease on the mound and plus money on the board, we’re backing the Padres to take care of business on the road.

Padres vs. Astros Pick

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