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Gonzaga vs. Houston Prediction, Pick, Latest March Madness Odds for Round of 32

The Houston Cougars are looking to advance to another Sweet 16, but face a ferocious opponent in the Gonzaga Bulldogs tonight. Can LJ Cryer and the Cougars hold off a late charge from Gonzaga in the Round of 32? Next Level Bets is backing the experienced squad in his Gonzaga vs. Houston prediction and pick for Saturday night.

Gonzaga vs. Houston Prediction, Pick, Latest March Madness Odds for Round of 32

We’ve got an absolute banger tonight as two powerhouse programs, Houston and Gonzaga, go head-to-head with a trip to the Sweet 16 of March Madness on the line. Both squads have been playing at a high level, and this game is shaping up to be one of the best matchups of the tournament so far. One team will advance — the question is, who will step up under the bright lights?

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Gonzaga vs. Houston Odds

  • ML: Gonzaga +190, Houston -220
  • Spread: Gonzaga +5.5 (-110), Houston -5.5 (-110)
  • Total: Over 141.5 (-110), Under 141.5 (-108)

Gonzaga vs. Houston Date, Time, and Where to Watch

  • Date: Saturday, March 22, 2025
  • Time: 8:40 PM ET
  • Where to Watch: TNT

Click here for latest Gonzaga vs. Houston Odds

Gonzaga vs. Houston Prediction

This is the game on the slate tonight — Houston vs. Gonzaga — and both teams have been on fire. Gonzaga has really found their stride lately, looking like the squad many expected them to be all season. They’re coming off an absolute beatdown of Georgia, where they dominated from start to finish and showed just how dangerous they can be when they’re locked in.

But now they face a different animal in Houston. This team has been money all year — consistent, dominant, and poised. They’ve looked like one of the most complete teams in college basketball, locking down opponents with their elite defense and knocking down shots from deep with confidence, led by LJ Cryer.

Gonzaga has the talent and momentum, no doubt, but Houston’s consistency, defensive pressure, and ability to control the pace give them the edge in this matchup. I expect this to be a close game early, but Houston’s defense and shooting from beyond the arc should be the difference as they pull away late.

I like Gonzaga, but I trust Houston more — they've been too consistent and too dominant all season long. This should be a great game, but in the end, I’m riding with Houston to get the win and cover the spread.

Gonzaga vs. Houston Pick

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