Sodiq Yusuff vs. Mairon Santos Prediction, Betting Pick, Latest Odds for UFC Fight Night Las Vegas
Sodiq Yusuff and Mairon Santos will square off from UFC Fight Night in Las Vegas as part of the main card tonight. Can Yusuff bounce back from two straight losses, or will Santos hand him another as the slight favorite? Jason Radowitz gives his prediction and best betting pick for Sodiq Yusuff vs. Mairon Santos at UFC Fight Night on Saturday, May 17th.

Jason Radowitz
| 5 min
Sodiq Yusuff vs. Mairon Santos Prediction, Betting Pick, Latest Odds for UFC Fight Night Las Vegas
After back-to-back losses since 2023, Sodiq Yusuff will look to get back on track with an exciting matchup against Mairon Santos at UFC Fight Night: Burnes vs. Morales. Meanwhile, Santos defeated Kaan Ofli in August 2024, which earned him the Ultimate Fighter Title. He used that momentum to earn a win in March against Francis Marshall and will look to continue to climb the ranks with a matchup against Yusuff next. Yusuff is an experienced fighter in this matchup. However, Santos has elite defense and is arguably the better striker. It's why he's currently the slight favorite heading into Saturday.
Should we back the up-and-comer over the veteran? Here are our picks, predictions, and odds for the UFC Fight Night bout between Sodiq Yusuff vs. Mairon Santos.
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Sodiq Yusuff vs. Mairon Santos Odds
- Moneyline: Yusuff (+115), Santos (-135)
Sodiq Yusuff vs. Mairon Santos Date, Time, and Where to Watch
- Date: Saturday, May 17, 2025
- Time: 7:00 PM ET (Main Card)
- Where to Watch: ESPN+
Click here for complete Yusuff vs. Santos odds
Sodiq Yusuff vs. Mairon Santos Prediction
Sodiq Yusuff has lost two consecutive bouts, including a TKO by Deigo Lopes in less than 90 seconds on April 13, 2024. Yusuff hasn't fought since that fight and is currently 2-3 in his last five matches.
Yusuff never had a chance against Lopes, but he looked strong enough to start in his prior match against Edson Barboza. However, after a good round 1, Barboza returned with kicks and pressure and took advantage of Yusuff's late-fight vulnerability.
On the other hand, Santos isn't a high-volume striker. He's typically a strong defender and looks to counter strike with precision.
But while he doesn't give out much striking, he also doesn't take much.
Ultimately, Santos has been poor with his takedown defense, but Yusuff isn't much of a wrestler. That's what makes this matchup so intriguing. As long as Santos keeps this fight standing, his cardio and striking defense should be enough to get the win.
Sodiq Yusuff vs. Mairon Santos Pick
- Pick: Santos ML (-135) Click here to see which sportsbook has the best odds for Yusuff vs. Santos
MMA ODDS & PICKS
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